ABC multidrug transporters: structure, function and role in chemoresistance.
By F. Sharom. Pharmacogenomics (London), 2008
984 citations recorded by the source corpus.
Subfields: Oncology, Pediatrics, Perinatology and Child Health, Pharmacology
View Paper: https://www.semanticscholar.org/paper/debe78a2e285ed2c569900ebfd0d3ff0f34fbdc3
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Oncology
- Olivier Michielin
- Vincent Zoete
- Antoine Daina
- H. Lai
- M. Chan
- Tim Hui-Ming Huang
- Pearlly Yan
- Kenneth P. Nephew
In Pediatrics, Perinatology and Child Health
- H. Lai
- M. Chan
- Tim Hui-Ming Huang
- Vincent Zoete
- Olivier Michielin
- Pearlly Yan
- Kenneth P. Nephew
- Antoine Daina
In Pharmacology
- Vincent Zoete
- Olivier Michielin
- Antoine Daina
- H. Lai
- M. Chan
- Tim Hui-Ming Huang
- Pearlly Yan
- Kenneth P. Nephew
Citations in the corpus
- Mechanisms of Chemotherapy Resistance in Triple-Negative Breast Cancer—How We Can Rise to the Challenge (2019, background): “A number of ABC transporters are strongly implicated in chemoresistance of numerous solid tumors, including breast cancer [14].”
- Structure and mechanism of ABC transporters (2015, background): “Much effort has been spent on identifying selective inhibitors for these MDR transporters and while many compounds have been identified that inhibit P-glycoprotein function in, for example, human cell culture, no broadly applicable inhibitor is in use as of yet, due to significant side effects of th”
- SwissADME: a free web tool to evaluate pharmacokinetics, drug-likeness and medicinal chemistry friendliness of small molecules (2017, positive): “Importantly as well, P-gp is overexpressed in some tumour cells and leads to multidrug-resistant cancers 42 .”
- Identification and characterization of ovarian cancer-initiating cells from primary human tumors. (2008, methodology): “We also assessed expression of ABCG2 , encoding a membrane efflux transporter expressed in hematopoietic stem cells and also associated with chemotherapy resistance (38).”
- Drug resistance and combating drug resistance in cancer (2019, background): “It can transport both positively- or negatively-charged drugs, ranging from chemotherapeutic drugs (mitoxantrone, bisantrene, epipodophyllotoxin, camptothecins, flavopiridol and anthracyclines) to several TKIs (imatinib and gefitinib)[48,59,60].”