The Drosophila microRNA Mir-14 suppresses cell death and is required for normal fat metabolism.

By Peizhang Xu, Stephanie Y. Vernooy, M. Guo, B. Hay. Current Biology, 2003

1,037 citations recorded by the source corpus.

Subfields: Biochemistry, Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/e782af10d3bdc4a0e6ca259fc3db6473ad8459e3

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Citations in the corpus

MicroRNAs: key players in the immune system, differentiation, tumorigenesis and cell death (2008, background): “Furthermore, miR-14 was found to suppress pro-apoptotic activity of reaper during the eye formation (Xu et al., 2003).”
MicroRNAs in stress signaling and human disease (2012, background): “…and undergoing extra cell divisions in adults (Lee et al., 1993; Reinhart et al., 2000). miRNAs were subsequently identified in Drosophila that regulate cell proliferation and apoptosis, further linking these regulatory RNAs to cancer-relevant pathways (Brennecke et al., 2003; Xu et al., 2003).”
Microarray analysis of microRNA expression in the developing mammalian brain (2004, background): “In Drosophila, the microRNAs bantam and mir-14 act in the regulation of cell growth and cell death [20,21].”
Argonaute—a database for gene regulation by mammalian microRNAs (2005, neutral): “miRNAs are involved in several cellular processes, including cellular differentiation (7,8), organism development (9,10) and apoptosis (11,12).”
MicroRNA functions in animal development and human disease (2005, background): “Function of animal microRNAs in vivo Process microRNA Targets Function Evidence Key citations C. elegans Developmental timing lin-4 microRNA lin-14, lin-28 Stem cell differentaition LOF Lee et al., 1993; Wightman et al., 1993 Developmental timing let-7 microRNA lin-41, hbl-1, Stem cell differentaiti”
A pancreatic islet-specific microRNA regulates insulin secretion (2004, background): “Furthermore, genetic studies in these organisms have identified important functions of specific miRNAs in the coordination of cell proliferation and cell death during development and in fat metabolis”
High expression of precursor microRNA‐155/BIC RNA in children with Burkitt lymphoma (2004, background): “There have been two recent reports in which a direct functional involvement of microRNA genes in the regulation of cell proliferation, apoptosis, and fat metabolism were documented in a set of elegantly performed experiments (Brennecke et al., 2003; Xu et al., 2003).”
Small non-coding RNAs in animal development (2008, background): “Bantam, miR-2, miR-6 and miR-14 regulate tissue growth through modulation of both apoptosis and cell proliferatio”
MicroRNA pathways in flies and worms: growth, death, fat, stress, and timing. (2003, methodology): “The temporal regulation of hbl-1 (hunchback)cytes, perhaps as part of a stress response pathway (Xu et al., 2003). expression is complex, involving both transcriptional (red “?”) andThe cell death activators hid and Drice are potential posttranscripposttranscriptional (black “?”) repression.tional…”