A pancreatic islet-specific microRNA regulates insulin secretion

By Matthew N. Poy, L. Eliasson, J. Krutzfeldt, S. Kuwajima, Xiaosong Ma, P. MacDonald, S. Pfeffer, Thomas Tuschl, Nikolaus Rajewsky, P. Rorsman and 1 more. Nature, 2004

2,159 citations recorded by the source corpus.

Subfields: Cancer Research, Plant Science, Surgery

View Paper: https://www.semanticscholar.org/paper/83d2dea92922f771fcff95bf560c91404cafc11d

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Citations in the corpus

Comprehensive analysis of microRNA expression patterns in hepatocellular carcinoma and non-tumorous tissues (2006, background): “The biological functions and targets of some miRNAs have been recently reported. miR-143 has been associated with adipocyte differentiation and the target of this miRNA is ERK5 (Esau et al., 2004). miR-375 regulates insulin secretion by modulating the expression of myotropin (Poy et al., 2004).”
microPrimer: the biogenesis and function of microRNA (2005, background): “…cloning from glucoseresponsive murine pancreatic cell lines, suppresses glucoseinduced insulin secretion by repressing myotrophin (Mtpn) expression (Poy et al., 2004). miRNA expression profiling has also identified a zebrafish miRNA that regulates brain morphogenesis, miR-430, whose expression…”
Principles of MicroRNATarget Recognition (2005, background): “was found to be a pancreatic-islet-specific miRNA that regulates insulin secretion [”
Extracellular miRNAs: From Biomarkers to Mediators of Physiology and Disease (2019, background): “miR-375 is highly enriched in pancreatic islets where it suppresses glucose-stimulated insulin secretion by targeting myotrophin (MTPN), a protein involved in fusion of insulincontaining granules with the plasma membrane (Poy et al., 2004; Xia et al., 2011), and 3phosphoinositide-dependent kinase 1 ”
Expression profiling identifies microRNA signature in pancreatic cancer (2006, background): “While the role for each of these miRNAs is unknown, specific miRNAs have been implicated in the regulation of a diverse number of cellular processes, including differentiation of adipocytes,(9) maturation of oocytes,(10) maintenance of the pluripotent cell state(11) and regulation of insulin secreti”
Principles of MicroRNA–Target Recognition (2005, neutral): “miRNA that regulates insulin secretion [22].”
TransmiR: a transcription factor–microRNA regulation database (2009, background): “This binding results in cleavage or translation inhibition of the target mRNAs (1–3). miRNAs play critical roles in many essential biological processes, such as proliferation (4,5), metabolism (6,7), diﬀerentiation (8), development (9,10), apoptosis (7,11,12) and cellular signaling (13).”
Prediction and validation of microRNAs and their targets (2005, neutral): “ter-gene constructs [37,40,51,53,54], mutation studies [38– 43,53], gene-silencing techniques [4,53,54], rescue assays [7], and classic genetic studies [2,5–8,54].”