The importance of repairing stalled replication forks

By M. Cox, Myron F. Goodman, K. Kreuzer, D. Sherratt, S. Sandler, K. Marians. Nature, 2000

1,073 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/e63205c7d3bb99490a365d74cdf566db3073c832

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Citations in the corpus

ATR: An Essential Regulator of Genome Integrity (2008, neutral): “Even on the relatively small circular Escherichia coli genome, it is estimated that nearly all of the replication forks encounter lesions that must be repaired during every round of replication, even in normal growth condition”
How antibiotics kill bacteria: from targets to networks (2010, background): “, inhibition of topoisomerase function by quinolone antibiotics and the resulting formation of stable complexes with DNA have substantial negative consequences for the cell in terms of its ability to deal with drug-induced DNA damag”
Oxidative Stress Resistance in Deinococcus radiodurans (2011, background): “The RecA-mediated invasion of a homologous duplex by ssDNA forms a D loop (109).”
Chromosomal stability and the DNA double-stranded break connection (2001, neutral): “Repair of the DSB and the restart of replication are assisted by H”
Homologous recombination and human health: the roles of BRCA1, BRCA2 and associated proteins (2015, background): “Thus, a critical function of HR is likely to be the repair of replication-associated damage (see Syeda et al. 2014), as is the case in bacteria (Cox et al. 2000).”
Supplementary Materials for Direct Observation of Stalled Fork Restart via Fork Regression in the T4 Replication System (2012, methodology): “The data thus obtained under pseudo first-order conditions were then fit to a single exponential equation (1) to obtain the rate constant for enzymecatalyzed annealing under ensemble conditions.”
DNA double-strand break repair: from mechanistic understanding to cancer treatment. (2007, background): “There is now substantial data supporting the notion that homology directed repair is critical for repair at the replication fork [83].”
Cellular roles of DNA topoisomerases: a molecular perspective (2002, background): “The recombination field itself is undergoing a sea change, and the importance of recombinational repair of DNA damage, and in restoring stalled replication forks, has received increasing attentio”
BRCA2 is required for homology-directed repair of chromosomal breaks. (2001, background): “…described gene-targetingmain function of homologous recombination under norvector, p59 (te Riele et al., 1990), to contain XhoI sites flanking mal growth conditions is to restart stalled replication the targeting arms (p59x) and the DR-GFP recombination substrate forks (Cox et al., 2000).”
Cell cycle checkpoint signaling through the ATM and ATR kinases. (2001, background): “Indeed, studies in bacteria suggest that S phase cells rely heavily on homologous recombination to restart stalled replication forks, even in the absence of genotoxic agents (Cox 1999; Cox et al. 2000).”
Toward maintaining the genome: DNA damage and replication checkpoints. (2002, background): “Much of the current interest in replication fork biology has been motivated by findings in bacteria where replication fork collapse is thought to be a common feature (occurring about once in every two cell divisions), with RecA acting to restore failed forks by homologous recombination (41).”
RecQ helicases: caretakers of the genome (2003, background): “There are several potential strategies for restoring replication following fork demise, and the choice of which to use probably depends on the type of lesion and the template strand that is damaged (for recent reviews, see Ref”