BRCA2 is required for homology-directed repair of chromosomal breaks.

By M. Moynahan, A. Pierce, M. Jasin. Molecules and Cells, 2001

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DNA repair pathways as targets for cancer therapy (2008, background): “BRCA1 - and BRCA2 -mutated cells are defective in HR repai”
Inherited Mutations in Women with Ovarian Carcinoma (2016, neutral): “None 1568 62 (23-91) 37 35 1117 376 1208 66 55 11 131 53 20 16 8”
Insights into DNA recombination from the structure of a RAD51–BRCA2 complex (2002, background): “Indeed, BRCA2 deficiency leads to a severe defect in the repair of DNA double-strand breaks by recombinatio”
PARP Inhibitors: The First Synthetic Lethal Targeted Therapy (2017, background): “The preferential use of these non-conservative repair mechanisms in the absence of HRR therefore often leads to DNA alterations including deletions of genetic material (15-17).”
Role of RAD52 Epistasis Group Genes in Homologous Recombination and Double-Strand Break Repair (2002, background): “Furthermore, cell lines expressing hypomorphic alleles of BRCA2 exhibit chromosome instability, radiation sensitivity, and defective homologous recombination (252, 332, 412, 430).”
BRCA1 and BRCA2: different roles in a common pathway of genome protection (2011, background): “BRCA2 mediates the recruitment of the recombinase RAD51 to DSBs; RAD51 recruitment is not only essential for HR but is also responsible for the tumour-suppressive function of this repair proces”