New approaches to antidepressant drug discovery: beyond monoamines

By O. Berton, E. Nestler. Nature Reviews Neuroscience, 2006

1,597 citations recorded by the source corpus.

Subfields: Biological Psychiatry, Cellular and Molecular Neuroscience, Pharmacology

View Paper: https://www.semanticscholar.org/paper/e60327cc81b6703f3d1575ec2883eed0f259f4a8

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biological Psychiatry

1. J. Cryan
2. Ted G. Dinan
3. E. Nestler
4. G. Clarke
5. P. Kennedy
6. C. Stanton
7. R. Duman
8. Jaak Panksepp

In Cellular and Molecular Neuroscience

1. R. Duman
2. E. Nestler
3. R. Hen
4. H. Schmidt
5. Amar Sahay
6. Jaak Panksepp
7. D. Watt
8. W. Renthal

In Pharmacology

1. R. Duman
2. R. Hen
3. E. Nestler
4. J. R. Kelly
5. H. Schmidt
6. P. Kennedy
7. Amar Sahay
8. Ted G. Dinan

Citations in the corpus

• Linking Molecules to Mood: New Insight Into the Biology of Depression (2010, neutral): “neurotrophic and cytokine signaling cascades, ion channels, HDACs, circadian genes (87,107), transcription factors (e.”
• The molecular neurobiology of depression (2008, neutral): “Neural circuitry of depression Several brain regions and circuits regulate emotion, reward and executive function, and dysfunctional changes within these highly interconnected 'limbic' regions have been implicated in depression and antidepressant actio”
• Transferring the blues: Depression-associated gut microbiota induces neurobehavioural changes in the rat. (2016, background): “The complex aetiology, involves dysregulated neuroendocrine (Stetler and Miller, 2011) neuroimmune (Dowlati et al., 2010), metabolic (Jokela et al., 2014) and neurotransmitter systems (Berton and Nestler, 2006).”
• Beyond classical benzodiazepines: Novel therapeutic potential of GABAA receptor subtypes (2011, background): “Although there is tremendous interest in developing antidepressant agents that utilize different mechanisms of action, the development of such agents has not yet been successfu”
• A standardized protocol for repeated social defeat stress in mice (2011, neutral): “Experimental control over the intensity of social defeat stress exposure makes it possible to examine a wide range of individual responses across molecular, cellular and behavioral endpoint”
• Epigenetic regulation in psychiatric disorders (2007, background): “Although many patients benefit from antidepressant medication, electroconvulsive seizures (ECS) or psychotherapy, only about half of depressed patients show a complete remission, which underscores the need for more effective agent”
• Depression: An Evolutionarily Conserved Mechanism to Terminate Separation Distress? A Review of Aminergic, Peptidergic, and Neural Network Perspectives (2009, background): “Currently, the mu-opioid system is almost totally neglected, even in excellent traditional reviews of depression (see Berton & Nestler, 2006); this neglect occurs despite abundant long-term evidence that opioid chemistries inform nearly every aspect of pleasure in mammalian brains (Berridge, 2004;…”
• The role of neurotrophic factors in adult hippocampal neurogenesis, antidepressant treatments and animal models of depressive-like behavior (2007, background): “The therapeutic action of currently available chemical antidepressants is only realized in a subset (approximately 50–70%) of patients with MDD and requires weeks to months of chronic treatment (Wong and Licinio, 2004; Berton and Nestler, 2006; Nemeroff, 2007).”
• Adult hippocampal neurogenesis in depression (2007, background): “Given the pleiotropic effects of antidepressants on neural circuitr”
• Rodent Models of Depression: Forced Swim and Tail Suspension Behavioral Despair Tests in Rats and Mice (2007, background): “Whereas development of novel approaches requires new animal models or intelligent use of existing models (Bosker et al., 2004; Berton and Nestler, 2006), there is still a need for a simple model with good predictive validity for early screening.”