Production of interleukin‐6 in contracting human skeletal muscles can account for the exercise‐induced increase in plasma interleukin‐6

By A. Steensberg, G. Hall, T. Osada, Massimo Sacchetti, B. Saltin, B. K. Pedersen. Journal of Physiology, 2000

1,095 citations recorded by the source corpus.

Subfields: Complementary and alternative medicine, Orthopedics and Sports Medicine, Rehabilitation

View Paper: https://www.semanticscholar.org/paper/e5d73cecfa29ce9ceb0de22a0657f0fa3680fe89

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In Complementary and alternative medicine

In Orthopedics and Sports Medicine

B. K. Pedersen

In Rehabilitation

Citations in the corpus

Immune function in sport and exercise. (2007, background): “The large increase in plasma IL-6 concentration observed during exercise can be entirely accounted for by release of this cytokine from contracting muscle fibers (51).”
Muscle‐derived interleukin‐6: possible biological effects (2001, background): “Recently, we demonstrated that the net IL-6 release from contracting skeletal muscles could more than account for the exercise-induced increase in arterial plasma concentrations (Steensberg et al. 2000).”
Muscles and their myokines (2011, background): “In the year 2000, it became clear that contracting human skeletal muscle releases significant amounts of interleukin (IL)-6 into the circulation during prolonged single-limb exercise (Steensberg et al., 2000).”
Role of myokines in exercise and metabolism. (2007, background): “In addition, it has been demonstrated that the IL-6 protein is expressed in muscle fibers postexercise (30) and that IL-6 is released from skeletal muscle during exercise (72, 73).”
Exercise is the real polypill. (2013, background): “IL-6 is probably the myokine prototype (366); its release by working muscles explains the consistently reported increase in blood IL-6 with exercise (118, 183, 212, 220, 278, 369, 411, 457, 458).”
Muscle–Organ Crosstalk: The Emerging Roles of Myokines (2020, background): “Our finding in 2000 that skeletal muscle produced and released interleukin-6 (IL-6) into the circulation (5) as well as research during the subsequent years, demonstrating that IL-6 has multiple metabolic effects in other parts of the body (6), identified IL-6 as an exercise factor and skeletal musc”
IL-6 enhances plasma IL-1ra, IL-10, and cortisol in humans. (2003, background): “The IL-6 gene is expressed within and released from contracting muscles (30), especially when intramuscular glycogen is low (14, 26).”
Age-related inflammatory cytokines and disease. (2003, background): “IL-6 mRNA is up-regulated in the human muscles during exercise [145,150,151] and in the electrically stimulated hind limbs of rats [152].”