The bioenergetic and antioxidant status of neurons is controlled by continuous degradation of a key glycolytic enzyme by APC/C–Cdh1

By Á. Herrero-Méndez, Á. Almeida, E. Fernandez, C. Maestre, S. Moncada, J. Bolaños. Nature Cell Biology, 2009

797 citations recorded by the source corpus.

Subfields: Cell Biology, Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/e596939dd164146c4bd4176c7dfeb05c68d41463

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Citations in the corpus

Brain metabolism in health, aging, and neurodegeneration (2017, positive): “The balance between glycolysis and PPP rates in neurons is very important, and diversion of glucose utilization toward exclusive glycolysis can result in decreased availability of NADPH, increased oxidative stress and cell death (Herrero-Mendez et al, 2009).”
Sugar for the brain: the role of glucose in physiological and pathological brain function (2013, background): “• Future research will elucidate the role of defective glucose metabolism and the extent of the involvement of members of the glycolytic cascade [72, 76-78] in the pathophysiology of neurodegenerative diseases.”
Astrocyte-neuron lactate transport is required for long-term memory formation (2011, neutral): “However, recent data by Herrero-Mendez et al. (2009) showed that cultured cortical neurons cannot sustain a high glycolytic rate as glucose is mainly used to maintain their antioxidant status, and studies in the skeletal muscle show that lactate is formed and utilized continuously under fully…”
Brain energy metabolism: focus on astrocyte-neuron metabolic cooperation. (2011, background): “…observed in vivo, i.e., a transient decrease in extracellular lactate levels after stimulation both in the human and rodent brain (Hu and Wilson, 1997; Mangia et al., 2003) followed by a sustained increase in extracellular lactate (Prichard et al., 1991; Hu and Wilson, 1997; Lin et al., 2010).”
An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex (2014, background): “Protein levels of Pfkfb3 are low in neurons because of its constant proteasomal degradation (Herrero-Mendez et al., 2009; Almeida et al., 2010),and,consistentwith these observations, we found that Pfkfb3 mRNA is enriched by an order of magnitude in astrocytes compared with neurons.”
13 reasons why the brain is susceptible to oxidative stress (2018, background): “A related corollary: neurons constitutively degrade the rate-limiting glycolytic enzyme, phosphofructokinase (PFK), to preferentially use glucose to power the pentose phosphate pathway (PPP) [95].”
Neuronal Cell Death. (2018, positive): “The generation of reduced glutathione (GSH) by preferential oxidation of glucose via the pentose phosphate pathway in neurons may therefore result in reduction of cytosolic cytochrome c to an extent sufficient to inhibit induction of caspase activity and subsequent apoptosis even after MOMP and cyto”
Regional aerobic glycolysis in the human brain (2010, background): “Recent work in cultured neurons places this figure considerably higher because of an apparently low level of phosphofructokinase-2 (PFK-2) in neurons (49).”