Regional aerobic glycolysis in the human brain

By S. Neil Vaishnavi, Andrei G. Vlassenko, Melissa M. Rundle, Abraham Z. Snyder, Mark A. Mintun, Marcus E. Raichle. Proceedings of the National Academy of Sciences of the United States of America, 2010

718 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/b17deaceaad0029721d0c00b2086671db99dcb9c

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Citations in the corpus

Energy metabolism of cancer: Glycolysis versus oxidative phosphorylation (Review). (2012, background): “However, glycolysis, an ancient energy production pathway preserved in evolution, still affects energy metabolism in certain human organs and tissues, such as the brain, liver and muscle (9,10), and is also a major energy production pathway in anaerobic bacteria.”
The hubs of the human connectome are generally implicated in the anatomy of brain disorders (2014, background): “Recent studies have also shown that hubs, especially in the cortex, have higher rates of cerebral blood flow, aerobic glycolysis and oxidative glucose metabolism (Vaishnavi et al., 2010; Liang et al., 2013; Tomasi et al., 2013).”
Cognitive Network Neuroscience (2015, background): “Perhaps even more interestingly, recent work has linked regional patterns of aerobic glycolysis to intrinsic functional connectivity (Vaishnavi et al., 2010).”
Network hubs in the human brain. (2013, background): “Several studies monitoring cortical blood flow and the metabolic activity of brain regions have indeed ranked cortical hubs among the metabolically most active areas of the cortex [158,159].”
Regulation of pyruvate metabolism and human disease (2013, background): “The DMN contains a high percentage of astrocytes [206] and is thought to play an important role in memory retrieval, and may be perturbed in Alzheimer’s disease [207].”
The Restless Brain (2011, neutral): “This ﬁgure was reproduced with permission from Ress et al. (2000).”
The return of metabolism: biochemistry and physiology of the pentose phosphate pathway (2014, background): “Most patients display first symptoms in the neonatal or antenatal period, with prenatal intra-uterine growth retardation, oligohydramnios and hydrops foetalis being described (Valayannopoulos et al., 2006).”
Trends and Properties of Human Cerebral Cortex: Correlations with Cortical Myelin Content (2013, positive): “Vaishnavi et al. (2010) argued that increased synaptic plasticity might be one reason for elevated aerobic glycolysis.”
neuromaps: structural and functional interpretation of brain maps (2022, background): “Collectively, these maps represent more than a decade of human brain mapping research and encompass phenotypes including: the first principal component of gene expression [33], 36 neurotransmitter receptor PET tracer images [32], glucose and oxygen metabolism [72], cerebral blood flow and volume [72”
Coupling of functional connectivity and regional cerebral blood flow reveals a physiological basis for network hubs of the human brain (2013, methodology): “It has been shown that regional cerebral blood flow (rCBF) is closely coupled with glucose utilization, oxygen consumption, and aerobic glycolysis in resting brains (9, 10).”
Altered Resting State Complexity in Schizophrenia (2011, neutral): “(Vaishnavi et al., 2010).”
A Predictive Network Model of Cerebral Cortical Connectivity Based on a Distance Rule (2013, neutral): “The correlation of the rich club to regions of high metabolism further emphasizes the high cost of the rich club and points to a potential link with degenerative brain disorders (Bullmore and Sporns, 2012; Collin et al., 2013; Vaishnavi et al., 2010).”
Neurodevelopment of the association cortices: Patterns, mechanisms, and implications for psychopathology (2021, neutral): “…Huntenburg et al., 2017; Paquola et al., 2019a), areal allometric scaling (Reardon et al., 2018), cerebral metabolism (Satterthwaite et al., 2014; Vaishnavi et al., 2010), cortico-cortical connectivity distance (Bazinet et al., 2020; Oligschl€ager et al., 2017; Sepulcre et al., 2010), functional…”
Structural foundations of resting-state and task-based functional connectivity in the human brain (2013, background): “Structural connections are unevenly distributed between different regions of the brain (17).”
A cellular perspective on brain energy metabolism and functional imaging. (2015, background): “Indeed, 10% of glucose entering the brain yields lactate in a metabolic process known as aerobic glycolysis, which is the production of lactate in the presence of oxygen (Vaishnavi et al., 2010).”
The modular and integrative functional architecture of the human brain (2015, background): “Finally, connector node regions have been found to be metabolically demanding (91).”