Brain energy metabolism: focus on astrocyte-neuron metabolic cooperation.

By M. Bélanger, Igor Allaman, Pierre J. Magistretti. Cell Metabolism, 2011

2,160 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/3875761021a5b69d22138e5f849d300bcd2aa3f1

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. Igor Allaman
2. Pierre J. Magistretti
3. Jie Zheng
4. Hugo J. Bellen
5. B. Barres
6. M. Sofroniew

In Molecular Biology

1. Igor Allaman
2. R. Daneman
3. B. Barres
4. Pierre J. Magistretti
5. E. Sanz
6. Jie Zheng
7. P. Lei
8. S. A. Liddelow

In Physiology

1. Igor Allaman
2. Pierre J. Magistretti
3. Jie Zheng
4. S. A. Liddelow
5. B. Barres
6. R. Daneman

Citations in the corpus

• The return of metabolism: biochemistry and physiology of the pentose phosphate pathway (2014, background): “Glucose represents the normal obligatory energy substrate of the brain, and 25% of its daily intake is assumed to be dedicated to cerebral functions (Cremer, 1982; Bélanger et al., 2011).”
• Ferroptosis: mechanisms and links with diseases (2021, background): “Due to its high metabolic activity, brain tissues are particularly vulnerable to oxidative stress.(225) Increased oxidative stress is a feature of several neurodegenerative diseases, including Alzheimer’s disease(226) and Parkinson’s disease.”
• Energy metabolism of cancer: Glycolysis versus oxidative phosphorylation (Review). (2012, background): “Lactate released by astrocytes can be taken up by neurons, used as energy fuel and form the so-called astrocyte-neuron lactate shuttle (ANLS) (29).”
• An RNA-Sequencing Transcriptome and Splicing Database of Glia, Neurons, and Vascular Cells of the Cerebral Cortex (2014, background): “…because the primary energy consumers in the brain, neurons and astrocytes, each exhibit diametric patterns of glucose consumption (for review, see Bélanger et al., 2011; Bouzier-Sore and Pellerin, 2013); neurons heavily rely on oxidative metabolism, whereas astrocytes exhibit high glycolytic…”
• A cellular perspective on brain energy metabolism and functional imaging. (2015, background): “These features endow astrocytes with the capacity to sustain high levels of glycolysis, as they can detoxify MG, and to protect neurons against MG toxicity (Bélanger et al., 2011b).”
• Glial Lipid Droplets and ROS Induced by Mitochondrial Defects Promote Neurodegeneration (2015, positive): “A growing body of evidence points to the importance of glial health and function in nervous system energy metabolism and homeostasis (Belanger et al., 2011).”
• 13 reasons why the brain is susceptible to oxidative stress (2018, neutral): “port neuronal activity [91] (corresponding to ~5.”