Immunosenescence and Inflamm-Aging As Two Sides of the Same Coin: Friends or Foes?
By T. Fulop, A. Larbi, G. Dupuis, A. Le Page, E. Frost, A. Cohen, J. Witkowski, Claudio Franceschi. Frontiers in Immunology, 2018
1,190 citations recorded by the source corpus.
The immune system is the most important protective physiological system of the organism. It has many connections with other systems and is, in fact, often considered as part of the larger neuro–endocrine–immune axis. Most experimental data on immune changes with aging show a decline in many immune parameters when compared to young healthy subjects. The bulk of these changes is termed immunosenescence. Immunosenescence has been considered for some time as detrimental because it often leads to subclinical accumulation of pro-inflammatory factors and inflamm-aging. Together, immunosenescence and inflamm-aging are suggested to stand at the origin of most of the diseases of the elderly, such as infections, cancer, autoimmune disorders, and chronic inflammatory diseases. However, an increasing number of immune-gerontologists have challenged this negative interpretation of immunosenescence with respect to its significance in aging-related alterations of the immune system. If one considers these changes from an evolutionary perspective, they can be viewed preferably as adaptive or remodeling rather than solely detrimental. Whereas it is conceivable that global immune changes may lead to various diseases, it is also obvious that these changes may be needed for extended survival/longevity. Recent cumulative data suggest that, without the existence of the immunosenescence/inflamm-aging duo (representing two sides of the same phenomenon), human longevity would be greatly shortened. This review summarizes recent data on the dynamic reassessment of immune changes with aging. Accordingly, attempts to intervene on the aging immune system by targeting its rejuvenation, it may be more suitable to aim to maintain general homeostasis and function by appropriately improving immune-inflammatory-functions.
Subfields: Aging, Epidemiology, Neurology
View Paper: https://www.semanticscholar.org/paper/4f791568b90d527aa0388f5fdc2c3e092f1e15b3
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Citations in the corpus
- Inflammation and aging: signaling pathways and intervention therapies (2023, background): “To further explain aging from the perspective of harmful inflammation and weakened immunity, inflammaging was introduced as an evolutionary perspective on immunosenescence, referring to the phenomenon of low-grade, chronic damage resulting from increased inflammation levels within the body.(2) Later”
- The Continuum of Aging and Age-Related Diseases: Common Mechanisms but Different Rates (2018, background): “We recently argued that the adaptive hormetic paradigm could be applied to inflammaging (287) as well as to lifestyle such as Mediterranean diet, which counteract the deleterious effects of inflammaging (283).”
- Measuring biological aging in humans: A quest (2019, background): “Interestingly, all of the “hallmarks of aging” cited above directly or indirectly cause an inflammatory state, suggesting that the pro-inflammatory state observed in many older persons may reflect the burden of biological aging (Ferrucci et al., 2005; Franceschi & Campisi, 2014; Fulop et al., 2018).”