The Adverse Effects of Air Pollution on the Nervous System
By Ş. Genç, Z. Zadeoğluları, S. Fuss, K. Genc. Journal of Toxicology, 2012
644 citations recorded by the source corpus.
Exposure to ambient air pollution is a serious and common public health concern associated with growing morbidity and mortality worldwide. In the last decades, the adverse effects of air pollution on the pulmonary and cardiovascular systems have been well established in a series of major epidemiological and observational studies. In the recent past, air pollution has also been associated with diseases of the central nervous system (CNS), including stroke, Alzheimer's disease, Parkinson's disease, and neurodevelopmental disorders. It has been demonstrated that various components of air pollution, such as nanosized particles, can easily translocate to the CNS where they can activate innate immune responses. Furthermore, systemic inflammation arising from the pulmonary or cardiovascular system can affect CNS health. Despite intense studies on the health effects of ambient air pollution, the underlying molecular mechanisms of susceptibility and disease remain largely elusive. However, emerging evidence suggests that air pollution-induced neuroinflammation, oxidative stress, microglial activation, cerebrovascular dysfunction, and alterations in the blood-brain barrier contribute to CNS pathology. A better understanding of the mediators and mechanisms will enable the development of new strategies to protect individuals at risk and to reduce detrimental effects of air pollution on the nervous system and mental health.
Subfields: Health, Toxicology and Mutagenesis, Pollution
View Paper: https://www.semanticscholar.org/paper/8495e1d4dc18351b6d29db7bd1f5b3272227ded8
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Citations in the corpus
- Recent Advances in Electrochemical Sensors for Detecting Toxic Gases: NO2, SO2 and H2S (2019, background): “The noteworthy impacts of NO2 include: respiratory inflammation of the airways, decreased lung function due to long term exposure, increased risk of respiratory conditions [4,5], increased responsiveness to allergens, contribution to the formation of fine particulate matter (PM) and ground level ozo”
- Environmental and Health Impacts of Air Pollution: A Review (2020, background): “The mechanisms in the development of neurodegenerative disease include oxidative stress, protein aggregation, inflammation, and mitochondrial impairment in neurons (104) (Figure 1).”