Supply and Demand in Cerebral Energy Metabolism: The Role of Nutrient Transporters

By I. Simpson, A. Carruthers, S. Vannucci. Journal of Cerebral Blood Flow and Metabolism, 2007

806 citations recorded by the source corpus.

Subfields: Clinical Biochemistry, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/e44b84e251666ae802f11d89f98dccf537ab99ef

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Clinical Biochemistry

1. Igor Allaman
2. Luc Pellerin
3. C. Zhong
4. Zhichun Chen
5. Pierre J. Magistretti

In Molecular Biology

1. G. Dienel
2. Igor Allaman
3. Pierre J. Magistretti
4. Luc Pellerin
5. C. Zhong
6. M. Bélanger
7. Zhichun Chen

In Physiology

1. Pierre J. Magistretti
2. Igor Allaman
3. Luc Pellerin
4. G. Dienel
5. C. Zhong
6. Zhichun Chen
7. Melissa A Brown
8. R. Ransohoff

Citations in the corpus

• Sugar for the brain: the role of glucose in physiological and pathological brain function (2013, background): “Here, glucose is predicted to be predominantly taken up into neurons due to their high energy demand and the higher transport rate of the neuronal glucose transporter, GLUT3, compared with the astrocytic glucose transporter, GLUT1 [16].”
• The blood-brain barrier in health and chronic neurodegenerative disorders. (2008, neutral): “…AA and monocarboxylic acids (lactate, pyruvate, ketone bodies); nucleosides (adenosine, guanosine, uridine); purines (adenine, guanine); amines (choline); and vitamins (Hawkins et al., 2006; Simpson et al., 2007; Ohtsuki and Terasaki, 2007; Deeken and Loscher, 2007; Spector and Johanson, 2007).”
• Sweet Sixteen for ANLS (2012, methodology): “Furthermore, in a recent article (Jolivet et al, 2010), we have pinpointed some major flaws in the modeling work proposed by DiNuzzo et al (2010a) and Simpson et al (2007).”
• The SLC2 (GLUT) Family of Membrane Transporters (2013, neutral): “Although it has been proposed that lactate produced by glycolysis in astrocytes is the primary fuel substrate for neurons, this hypothesis has been seriously challenged (Simpson et al., 2007).”
• BRAIN FUEL METABOLISM, AGING AND ALZHEIMER’S DISEASE (2010, background): “Astrocytes express MCT4, neurons express MCT2 and brain capillaries express MCT1 [166].”
• Brain energy metabolism: focus on astrocyte-neuron metabolic cooperation. (2011, background): “This is a central point of the astrocyte-neuron lactate shuttle (ANLS) model proposed over a decade ago by Pellerin and Magistretti (Figure 3A) (Pellerin andMagistretti, 1994).”
• Decoding Alzheimer's disease from perturbed cerebral glucose metabolism: implications for diagnostic and therapeutic strategies. (2013, background): “transportation and maintaining brain energy homeostasis, which readily take in glucose from blood through endothelial cells and convey energy metabolic substrates between blood and neurons (Erol, 2008; Simpson et al., 2007).”