The structural basis of lipopolysaccharide recognition by the TLR4–MD-2 complex

By B. Park, D. Song, Ho Min Kim, Byong-Seok Choi, Hayyoung Lee, Jie-Oh Lee. Nature, 2009

2,359 citations recorded by the source corpus.

Subfields: Epidemiology, Immunology, Microbiology

View Paper: https://www.semanticscholar.org/paper/e382296945d48d836ff49fb156a6c0355c435459

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Citations in the corpus

A Comparative Review of Toll-Like Receptor 4 Expression and Functionality in Different Animal Species (2014, background): “Binding of LPS also requires the MD-2 protein, which associates with the extracellular domain of TLR4 (34).”
Hyaluronan as an Immune Regulator in Human Diseases (2011, neutral): “However, MD-2 is usually associated with lipid recognition and binding (211, 336, 343).”
The Structural Biology of Toll-Like Receptors (2011, background): “The TLR-ECDs also contain structures that cap the N and C-terminal ends known as the LRR-NT and LRR-CT motifs, respectively (Figure 2).”
Impact of Obesity and Metabolic Syndrome on Immunity. (2016, background): “In addition to these functions, HDL may alter inflammatory responses by neutralizing LPS—an immunostimulatory glycolipid located on the outer membrane of Gram-negative bacteria that activates innate immune responses via pattern recognition receptors (110, 111).”
Pathogen Recognition by the Innate Immune System (2011, background): “Therefore, lipid A activates the TLR4 signaling pathway, but Eritoran does not [13, 14].”
INFLAMMATION AND LIPID SIGNALING IN THE ETIOLOGY OF INSULIN RESISTANCE (2012, neutral): “Structural considerations (Park et al., 2009) and direct binding assays (Schaeffler et al., 2009) argue against the possibility that SFAs are direct ligands for Tlr4.”
Initiation and perpetuation of NLRP3 inflammasome activation and assembly (2015, background): “If cardiolipin is a ligand for NLRP3 activation, it is possible that its recognition requires accessory proteins as is the case for TLR4/ MD2/Lipid A (160); therefore, determining other molecules that associate with the NLRP3 inflammasome complex is critical.”
Pattern recognition receptors and inflammation. (2010, background): “The crystal structure of a complex comprising TLR4, MD2, and LPS revealed that two complexes of TLR4-MD2-LPS interact symmetrically to form a TLR4 homodimer (Park et al., 2009).”
TLR4 and CD14 trafficking and its influence on LPS-induced pro-inflammatory signaling (2020, background): “A crystallographic analysis of the human TLR4/MD-2 complex with LPS bound has revealed that five of the six acyl chains of LPS are buried in the hydrophobic pocket of MD-2 while the sixth one interacts with TLR4 of another TLR4/MD-2 complex, and that the dimerization of the TLR4/MD-2 complexes is st”
Insights into secondary metabolism from a global analysis of prokaryotic biosynthetic gene clusters. (2014, background): “…Institute of Biotechnology, Faculty of Life Sciences, University of Manchester, Manchester M1 7DN, UK 12Present address: Max Planck Institute for Marine Microbiology, Celsiusstraße 1, 28359 Bremen, Germany *Correspondence: fischbach@fischbachgroup.org http://dx.doi.org/10.1016/j.cell.2014.06.034”