The mitochondrial deubiquitinase USP30 opposes parkin-mediated mitophagy

By Baris Bingol, Joy S. Tea, Lilian Phu, M. Reichelt, C. Bakalarski, Qinghua Song, O. Foreman, D. Kirkpatrick, Morgan Sheng. Nature, 2014

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Molecular mechanisms and physiological functions of mitophagy (2021, positive): “USP8, USP15, and USP30 regulate PINK1/Parkin-mediated mitophagy positively and negatively (Bingol et al , 2014; Cornelissen et al , 2014; Durcan et al , 2014; Cunningham et al , 2015; Liang et al , 2015).”
Measuring in vivo mitophagy (2015, background): “These properties have led to a mitochondrial-targeted form of Keima (mt-Keima) being increasingly employed to measure mitophagy in vitro (Bingol et al., 2014; Kageyama et al., 2014; Katayama et al., 2011; Mizumura et al., 2014).”
Deciphering the Molecular Signals of PINK1/Parkin Mitophagy. (2016, background): “The OMM-localized DUB ubiquitin-specific processing protease 30 (USP30) negatively regulates mitophagy through preferential hydrolysis of both K6- and K11-linked chains [36,37], indicating that both chain types are important for efficient mitophagy.”
The Roles of PINK1, Parkin and Mitochondrial Fidelity in Parkinson's Disease (2015, background): “Deubiquitinases (DUBs), such as USP30 (Bingol et al., 2014) and USP15 (Cornelissen et al., 2014), antagonize Parkin ubiquitin ligase activity by cleaving ubiquitin chains on mitochondria.”
Cellular mitophagy: Mechanism, roles in diseases and small molecule pharmacological regulation (2023, background): “The ubiquitin-specific peptidase 30 (USP30), a deubiquitinating enzyme found in mitochondria, is famous for its role in the regulation of mitochondrial morphology [149].”