Systemic RNAi in C. elegans Requires the Putative Transmembrane Protein SID-1

By William M Winston, C. Molodowitch, C. Hunter. Science, 2002

890 citations recorded by the source corpus.

Subfields: Aging, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/e322ebe921f39c3e1a65370110a5e3f31f065a33

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Aging

1. E. Miska
2. Suzanne C Wolff
3. Jenni Durieux
4. A. Dillin

In Molecular Biology

1. E. Miska
2. M. Soberón
3. C. Mello
4. L. Joshua-Tor
5. Javaregowda Nagaraju
6. A. Bravo
7. Sylvia Wong
8. Aditi D Singh

Citations in the corpus

• Analysis of the C. elegans Argonaute family reveals that distinct Argonautes act sequentially during RNAi. (2006, background): “In the strong loss-of-function sid-1(ne328) mutant, which has defects in dsRNA uptake and systemic transport to tissues in the body (Winston et al., 2002), RDE-1 exhibited a markedly reduced interaction with the 20-O-methyl target sequences (Figure 1E, lane 4).”
• RNA interference in Lepidoptera: an overview of successful and unsuccessful studies and implications for experimental design. (2011, background): “…identified in the moths Bombyx mori and Spodoptera exigua, as well as 196 in other insects such as Apis mellifera, Tribolium castaneum and aphids, but not in the D. 197 melanogaster genome (Winston et al., 2002; Honeybee Genome Sequencing Consortium, 198 2006; Xu and Han, 2008; Tian et al., 2009).”
• RNA Interference: Biology, Mechanism, and Applications (2003, background): “(231) constructed and used a special transgenic strain of C.”
• The Cell Non-Autonomous Nature of Electron Transport Chain-Mediated Longevity (2011, positive): “Life-Span Analysis of cco-1 Hairpin Transgenic Animals (A) Wild-type worms allow import of dsRNA from surrounding tissues, but sid-1(qt9) mutant worm can not import dsRNA and RNAi knockdown is no longer systemic but is maintained locally within the tissue in which the dsRNA is produced (Winston et a”
• Ingested double-stranded RNAs can act as species-specific insecticides. (2009, background): “SID-1, an RNA channel transporter first discovered in the nematode Caenorhabditis elegans (Winston et al., 2002), appears to facilitate uptake of dsRNA into cells, and this protein appears to be conserved in many but not all insect taxa (Gordon and Waterhouse, 2007).”