Ingested double-stranded RNAs can act as species-specific insecticides.

By S. Whyard, Aditi D Singh, Sylvia Wong. Insect Biochemistry and Molecular Biology, 2009

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RNA interference in Lepidoptera: an overview of successful and unsuccessful studies and implications for experimental design. (2011, methodology): “349 In studies involving dsRNA injection into other species of insects, direct correlations between 350 dose and the potency of RNAi have been noted (e.g. Arakane et al., 2005; Boisson et al., 351 2006; Whyard et al., 2009).”
Plant Virus Transmission by Insects (2009, background): “In aphids, RNAi-mediated gene silencing can reduce the expression of salivary gland proteins or kill the pea aphid, A. pisum when fed species-specific dsRNA targeting vATPase transcripts (Whyard et al., 2009).”
Chapter Five – Progress Towards RNAi-Mediated Insect Pest Management (2014, background): “Functional studies of genes involved in Drosophila development have relied on microinjection of dsRNA into embryonic tissue (e.g. Kennerdell and Carthew, 1998; Koizumi et al., 2007; Pilot et al., 2006).”
Literature review of baseline information on RNAi to support the environmental risk assessment of RNAi‐based GM plants (2018, background): “However, when a transfection agent such as Lipofectamine was added to the dsRNA solution, RNAi silencing was observed (Taning et al., 2016; Whyard et al., 2009).”