Compromised autophagy and neurodegenerative diseases

By Fiona M Menzies, Angeleen Fleming, D. Rubinsztein. Nature Reviews Neuroscience, 2015

790 citations recorded by the source corpus.

Subfields: Epidemiology, Neurology, Physiology

View Paper: https://www.semanticscholar.org/paper/e20cd3e8a903f6df061c7b6ee66ff4a5b6f6c906

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

In Neurology

In Physiology

Citations in the corpus

Molecular definitions of autophagy and related processes (2017, neutral): “…that activate or inhibit autophagy as novel therapies for multiple human disorders and pathophysiological conditions, including neurodegenerative (Menzies et al , 2015), infectious (Deretic et al , 2013), autoimmune (Deretic et al , 2013; Zhong et al , 2016), cardiovascular (Shirakabe et al ,…”
Mitophagy and Alzheimer’s disease: cellular and molecular mechanisms (2017, background): “To this end, there exist many mitochondrial quality control pathways such as misfolded protein degradation, fission and fusion, and the engulfment and degradation of damaged mitochondria, termed mitophagy (Figure 1) [15, 16].”
Emerging functions of the EGFR in cancer (2017, background): “…in different pathologies, including neurodegenerative diseases, aging, and cancer, and is one of the major mechanisms promoting resistance to cancer therapies (for recent reviews see, for instance Galluzzi et al., 2015, 2017; Goldsmith et al., 2014; Menzies et al., 2015; Rubinsztein et al., 2012).”
Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities. (2017, positive): “Knockdown of calpain in an Huntington’s disease Drosophila model (RNAi) results in upregulation of autophagy, reduction of huntingtin aggregate number and increases cell survival and is also protective against tau toxicity in HD and tauopathy models, respectively (Menzies et al., 2015b).”
Mechanisms of Autophagy Initiation (2017, background): “Excellent reviews cover the relationship of autophagy to neurodegeneration (5), cancer (6), aging (7), infection (8), and other diseases.”
Pathways of cellular proteostasis in aging and disease (2018, background): “The UPS mainly serves to target individual proteins to the proteasome, whereas the autophagy system clears larger aggregates or membrane-associated proteins (Menzies et al., 2015; Ciechanover and Kwon, 2017).”
Autophagy and Mitophagy in Cardiovascular Disease. (2017, background): “Intriguingly, this holds true for other tissues that mainly rely on mitochondrial respiration for ATP synthesis, such as the central nervous system.(48) Thus, it is tempting to speculate that the cardio- and neurodegenerative conditions spontaneously developing in the presence of autophagic or mitop”
TFEB at a glance (2016, background): “Growing evidence has established the accumulation of protein aggregates and autophagic and/or lysosomal dysfunction as the major pathogenic mechanisms underlying such diseases (Menzies et al., 2015).”
Hallmarks of neurodegenerative diseases. (2023, positive): “Consistent with autophagy being critical for neuronal health, deﬁciency of some atg genes, known to be critical for autophagy regulation, 129 causes neurodegeneration.”