1α,25-Dihydroxyvitamin D3 Inhibits Differentiation, Maturation, Activation, and Survival of Dendritic Cells Leading to Impaired Alloreactive T Cell Activation

By G. Penna, L. Adorini. Journal of Immunology, 2000

1,197 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/e1f6261ef7f0a1e58705b1147e5e0c7a739fe214

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

Citations in the corpus

Vitamin effects on the immune system: vitamins A and D take centre stage (2008, background): “The activity of 1,25(OH) 2 VD 3 on effector T-cell differentiation is further enhanced by its effect on antigen-presenting DCs, in which it suppresses the synthesis of IL-12, a cytokine that promotes T H 1-cell response”
Unexpected actions of vitamin D: new perspectives on the regulation of innate and adaptive immunity (2008, background): “By suppressing maturation of DCs and enhancing their expression of specific cytokines such as IL-10, 1,25(OH) 2 D can enhance tolerogenesis through the suppression of T H 1 lymphocyte development and the induction of T REG (see Figure 2 )”
Regulatory T Cells Induced by 1α,25-Dihydroxyvitamin D3 and Mycophenolate Mofetil Treatment Mediate Transplantation Tolerance1 (2001, background): “DCs matured in the presence of 1,25(OH)2D3 display reduced levels of MHC class II and CD40, CD80, and CD86 costimulatory molecules, and induce hyporesponsiveness in alloreactive T cells (24).”
DCs metabolize sunlight-induced vitamin D3 to 'program' T cell attraction to the epidermal chemokine CCL27 (2007, background): “It has been shown that 1,25(OH) 2 D 3 can inhibit the differentiation and maturation of DC”
Vitamin D signalling pathways in cancer: potential for anticancer therapeutics (2007, background): “However, in haematopoeitic progenitor cells, 1α,25(OH) 2 D 3 inhibits differentiation through VDR-independent suppression of interleukin 12 (IL12) protein secretion and down-regulation of other co-stimulatory molecules (CD40, CD80 and CD86”