Vitamin D signalling pathways in cancer: potential for anticancer therapeutics

By K. Deeb, D. Trump, Candace S. Johnson. Nature Reviews. Cancer, 2007

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The nonskeletal effects of vitamin D: an Endocrine Society scientific statement. (2012, background): “Studies of in vitro cell culture and in vivo experimental models suggest that 1,25-(OH)2D promotes cell differentiation, inhibits cancer cell proliferation, and exhibits antiinflammatory, proapoptotic, and antiangiogenic properties (163, 165, 166).”
Vitamin D—Effects on Skeletal and Extraskeletal Health and the Need for Supplementation (2013, background): “1,25(OH)2D3 might exert anti-carcinogenic effects by promoting various pro-apoptotic mechanisms including the downregulation of the anti-apoptotic gene Bcl-2 [154] and by upregulating of the pro-apoptotic gene Bax [155], 1,25(OH)2D3 induces differentiation, partly by reducing the expression of the c”
Molecular genetics of prostate cancer: new prospects for old challenges. (2010, background): “Another promising agent is vitamin D, which has been suggested by ample epidemiological evidence to protect against tumorigenesis, but has displayed variable efficacy in clinical trials (Deeb et al. 2007).”
Vitamin D and Clinical Outcomes in Head and Neck Cancer: A Systematic Review (2025, unknown): “In vitro and animal models further support these anti-cancer properties, showing reduced proliferation and metastasis in cancer cell lines exposed to 1,25(OH)2D [11].”