DCs metabolize sunlight-induced vitamin D3 to 'program' T cell attraction to the epidermal chemokine CCL27
By H. Sigmundsdóttir, Junliang Pan, G. Debes, Carsten Alt, Aida Habtezion, D. Soler, E. Butcher. Nature Immunology, 2007
672 citations recorded by the source corpus.
Subfields: Immunology, Pathology and Forensic Medicine
View Paper: https://www.semanticscholar.org/paper/720e88d240e052d70f3177a06d7e59bf7ace9c73
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In Pathology and Forensic Medicine
Citations in the corpus
- A Review of Micronutrients and the Immune System–Working in Harmony to Reduce the Risk of Infection (2020, background): “Vitamin D Homing of T cells to the skin [61]; calcitriol inhibits T-cell proliferation [7]; inhibitory effects mainly in adaptive immunity (e.”
- Vitamin D and human health: lessons from vitamin D receptor null mice. (2008, background): “chemotaxis caused by vitamin D deficiency, it was discovered more recently that 1,25-(OH)2D plays a role in microenvironmental positioning of T cells by altering their expression pattern of chemokine- and homing receptors (144).”
- Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells (2009, background): “The active metabolite of vitamin D 3 , 1,25(OH) 2 D 3 , which is produced in the skin by the action of sunlight, 'imprints' a skin-homing phenotype in association with IL-12, whereas the active metabolite of dietary vitamin A produced in the gut 'imprints' a gut-homing phenotyp”
- Phenotypic and functional specialization of FOXP3+ regulatory T cells (2011, background): “Moreover, 1,25-dihydroxyvitamin D3 produced by cutaneous DCs can induce T cell expression of CCR10, a chemokine receptor that is implicated in T cell localization to the epidermi”
- Unexpected actions of vitamin D: new perspectives on the regulation of innate and adaptive immunity (2008, background): “Recent data have shown that 1,25(OH) 2 D can contribute to this process by stimulating T lymphocyte expression of CC-chemokine receptor (CCR) 10, which recognizes the chemokine CCL27 that is secreted by keratinocytes”
- Strengthening the Immune System and Reducing Inflammation and Oxidative Stress through Diet and Nutrition: Considerations during the COVID-19 Crisis (2020, background): “, macrophages and dendritic cells, enabling vitamin D activation [227,228].”
- Chemokines and chemokine receptors: positioning cells for host defense and immunity. (2014, background): “However, this pathway may not be relevant in mice, which lack cutaneous vitamin D3 production and do not upregulate CCR10 in response to vitamin D3 (185).”