The Primary Cilium as the Cell's Antenna: Signaling at a Sensory Organelle

By Veena Singla, Jeremy F. Reiter. Science, 2006

1,174 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/e1bf8251fc4ded7a652b374bf2fcd4b920825b68

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Citations in the corpus

The Primary Cilium as a Complex Signaling Center (2009, background): “Cilia are assembled by the conserved process of intraflagellar transport (IFT); interestingly, it appears that this organelle has evolved into a complex signaling center in mammals, providing important sensory functions [2,3].”
The von Hippel–Lindau tumour suppressor protein: O2 sensing and cancer (2008, background): “Many cystic diseases are linked to abnormalities of the primary cilium, which is a specialized structure on the cell surface that has an important role in transduction of both chemical (for example, growth factor) and mechanical (for example, flow) signal”
Hedgehog signaling and primary cilia are required for the formation of adult neural stem cells (2008, background): “Recent work has shown that primary cilia concentrate receptors and signal transduction components that have vital roles in developmen”
BRAIN REGENERATION IN PHYSIOLOGY AND PATHOLOGY: THE IMMUNE SIGNATURE DRIVING THERAPEUTIC PLASTICITY OF NEURAL STEM CELLS (2011, background): “The function of this organelle in NPCs remains unknown, whereas recent works indicate that primary cilia are important sites for signal reception, particularly Sonic hedgehog homolog (Shh) (95, 216).”
The Glial Nature of Embryonic and Adult Neural Stem Cells (2009, background): “The function of this organelle in NSCs remains unknown, but as discussed below, recent work indicates that primary cilia are important sites for signal reception, particularly sonic hedgehog (Shh) (Huangfu & Anderson 2005, Singla & Reiter 2006).”
A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis. (2007, positive): “Recently, the cilium has become the focus of intensive studies for its role in the transduction of extracellular signals and in a constellation of genetic diseases (reviewed in Marshall and Nonaka, 2006; Scholey and Anderson, 2006; Singla and Reiter, 2006).”
Septins: the fourth component of the cytoskeleton (2012, background): “Another example is cilia, which are antenna-like projections that sense extracellular signals through membrane protein receptors and transmit them into the cell (for a review, see Ref”
Ciliogenesis: building the cell's antenna (2011, background): “Cilia also act as 'antennae' to sense extracellular signals, such as growth factors, hormones, odorants and developmental morphogen”
Centrioles, centrosomes, and cilia in health and disease. (2009, background): “functions are perturbed (Singla and Reiter, 2006).”
Proximal events in Wnt signal transduction (2009, background): “Primary cilia in Wnt signalling Primary cilia are non-motile, microtubule-based organelles that protrude from the plasma membrane of almost every eukaryotic cell and sense extracellular molecules and mechanical force”
HEF1-dependent Aurora A activation induces disassembly of the primary cilium. (2007, positive): “…Syndrome (BBS), and other disorders, mutations in cilia-associated structural or signaling proteins cause insensitivity to external mechanical and diffusible signaling cues, resulting in disorganized, hyperplastic cell growth (Benzing and Walz, 2006; Pan et al., 2005; Singla and Reiter, 2006).”