A core complex of BBS proteins cooperates with the GTPase Rab8 to promote ciliary membrane biogenesis.

By M. Nachury, A. Loktev, Qihong Zhang, Christopher J Westlake, J. Peränen, A. Merdes, Diane C. Slusarski, R. Scheller, J. Bazan, V. Sheffield and 1 more. Cell, 2007

1,429 citations recorded by the source corpus.

Subfields: Cell Biology, Genetics

View Paper: https://www.semanticscholar.org/paper/d3ffd1ca3eebe6c8def3ca07844161652b754b1c

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. J. Raff
2. Erich A. Nigg

In Genetics

1. S. Goetz
2. N. Katsanis
3. Erich A. Nigg
4. J. Raff
5. K. Anderson
6. P. Beales
7. Arturo Alvarez-Buylla

Citations in the corpus

• A Transition Zone Complex Regulates Mammalian Ciliogenesis and Ciliary Membrane Composition (2011, background): “Other ciliary localization sequences, such as that of Sstr3, bind the BBSome, a protein complex involved in BB”
• The Primary Cilium: A Signaling Center During Vertebrate Development (2010, background): “Some basal body proteins are required for cilia formation; evidence suggests that some may recruit cargo from the Golgi complex to the nascent ciliary membrane and others may promote loading of cargo into the axonem”
• Centrioles, centrosomes, and cilia in health and disease. (2009, background): “This appears to be the primary defect when intraflagellar transport is disrupted, or when ciliary membrane assembly is inhibited by mutations in Bardet-Biedl proteins (Nachury et al., 2007; Pazour et al., 2000).”
• Non‐syndromic retinitis pigmentosa (2018, neutral): “Moreover, the BBSome complex (in which BBS stands for Bardet-Biedl syndrome) serves as an adaptor between cargo and the IFT complex (Mourao et al., 2016; Nachury et al., 2007).”
• Photoreceptor degeneration: genetic and mechanistic dissection of a complex trait (2010, neutral): “For example, a complex involving seven BBS proteins (known as the BBSome) seems to regulate the docking and fusion of vesicles from the Golgi complex at the base of the connecting ciliu”
• Ciliopathies: an expanding disease spectrum (2011, background): “Ciliary targeting and assembly is mediated by several multiprotein complexes that include intraflagellar transport (IFT) proteins and the BBSome, a stable complex of at least eight BBS proteins (BBS 1, 2, 4, 5, 7, 8, 9 and BBIP10), which are modulated by members of the Arf and Rab family of proteins”