The von Hippel–Lindau tumour suppressor protein: O2 sensing and cancer

By W. Kaelin. Nature Reviews. Cancer, 2008

724 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/c2f6a4f6514c314a30540564e8372aa44c6ae458

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. D. Sinclair
2. C. Palmeira
3. A. Rolo
4. Eric L. Bell

Citations in the corpus

• HIF-1 mediates metabolic responses to intratumoral hypoxia and oncogenic mutations. (2013, neutral): “The genetic alteration that most dramatically increases HIF activity is VHL loss of function, which is the hallmark of the clear cell type of renal cell carcinoma (86).”
• Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging (2013, background): “HIFa proteins are regulated by a proteasomal degradation mechanism mediated by the Von Hippel-Lindau (VHL) E3 ubiquitin ligase that recognizes hydroxylated proline residues on HIFa (Kaelin, 2008).”