Hedgehog signaling and primary cilia are required for the formation of adult neural stem cells

By Young-Goo Han, Nathalie Spassky, M. Romaguera-Ros, Jose Manuel García-Verdugo, Andrea Aguilar, S. Schneider-Maunoury, Arturo Alvarez-Buylla. 2008

548 citations recorded by the source corpus.

Subfields: Genetics, Molecular Biology

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Genetics

1. Guo-li Ming
2. Hongjun Song
3. Thuc M. Le
4. G. Fan
5. S. Goetz
6. B. Yoder
7. Arturo Alvarez-Buylla
8. J. Sweatt

In Molecular Biology

1. Guo-li Ming
2. Hongjun Song
3. Arturo Alvarez-Buylla
4. A. Kriegstein
5. M. Götz
6. Thuc M. Le
7. G. Fan
8. S. Goetz

Citations in the corpus

• Adult Neurogenesis in the Mammalian Brain: Significant Answers and Significant Questions (2011, background): “Shh signaling is also activated in radial glia-like cells (Ahn and Joyner, 2005) and required for their establishment and maintenance in the adult SVZ and SGZ (Balordi and Fishell, 2007; Han et al., 2008).”
• In vivo fate mapping and expression analysis reveals molecular hallmarks of prospectively isolated adult neural stem cells. (2010, background): “Moreover, in the developing dentate gyrus, the second major neurogenic niche, cilia are required for the formation of aNSCs and regulate neurogenesis by mediating Shh signaling (Breunig et al., 2008; Han et al., 2008).”
• The Primary Cilium: A Signaling Center During Vertebrate Development (2010, background): “Primary cilia are also needed to modulate the SHH-dependent formation and maintenance of hippocampal granule neuron precursors, which are important for maintaining neurogenesis in adult”
• Adult Neurogenesis in the Hippocampus: From Stem Cells to Behavior. (2016, unknown): “Postnatal progenitors failed to develop after embryonic ablation of Smo in GFAP+ and Nestin+ neural precursor cells (Han et al., 2008).”
• Hedgehog Signaling in Development and Cancer (2008, unknown): “…establishment and/or maintenance of cilia and flagella affect Hh signaling in several developmental contexts, including neural tube patterning, limb development, and adult neural stem cell formation (Han et al., 2008; Haycraft et al., 2005; Huangfu et al., 2003; Liu et al., 2005; May et al., 2005).”
• Dnmt1 and Dnmt3a are required for the maintenance of DNA methylation and synaptic function in adult forebrain neurons (2010, methodology): “The BrdU + cells at the subgranular zone of the dentate gyrus were counted as describe”
• Development of neural stem cell in the adult brain. (2008, background): “Maintenance, proliferation, and fate specification of adult neural stem cells Continuous neurogenesis in the SVZ and SGZ throughout life suggests a sustained maintenance of adult NSCs. Hedgehog signaling is activated in quiescent adult NSCs [21] and appears to be required for both establishment and ”
• Lake-front property: a unique germinal niche by the lateral ventricles of the adult brain. (2011, unknown): “, 2008), and is essential for the formation of postnatal NSCs in the hippocampus (Han et al., 2008).”
• The Glial Nature of Embryonic and Adult Neural Stem Cells (2009, background): “At a critical developmental stage when embryonic progenitors divide to generate postnatal radial astrocytes, Shh signaling is essential for the formation and/or maintenance of this population of postnatal NSCs (Han et al. 2008).”
• Acquisition of granule neuron precursor identity is a critical determinant of progenitor cell competence to form Hedgehog-induced medulloblastoma (2008, unknown): “Third, we have recently shown that SmoM2 activation in the dentate gyrus causes hypertrophy but not cancer (Han et al., 2008).”