Life with Oxygen

By G. Semenza. Science, 2007

728 citations recorded by the source corpus.

Subfields: Cancer Research, Genetics, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/e1955fb867cb2b8efc7460370b331846ab15e11a

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cancer Research

1. M. C. Simon
2. Julian R. Jones
3. Bryan L. Krock
4. H. Eltzschig
5. Nicolas Skuli
6. T. Eckle
7. G. Semenza

In Genetics

1. M. C. Simon
2. Julian R. Jones
3. H. Eltzschig
4. T. Eckle

In Molecular Biology

1. M. C. Simon
2. Julian R. Jones
3. M. Trujillo
4. Bryan L. Krock
5. H. Eltzschig
6. Nicolas Skuli
7. T. Eckle
8. G. Semenza

Citations in the corpus

• Ischemia and reperfusion—from mechanism to translation (2011, background): “This metabolic switch is under the direct control of the HIF transcription factor, whose stabilization when oxygen levels fall is responsible for the transcriptional induction of glycolytic enzyme”
• Review of bioactive glass: from Hench to hybrids. (2013, background): “The hypothesis is that under normal oxygen pressure the hypoxia inducing factor 1a (HIF-1a) transcription factor is degraded via proteasome but under hypoxic conditions HIF-1a degradation is inhibited [287].”
• The Oxygen Rich Postnatal Environment Induces Cardiomyocyte Cell Cycle Arrest Through DNA Damage Response (2014, neutral): “Mitochondrial oxidative phosphorylation produces 18 times as much ATP as cytoplasmic glycolysis (Dismukes et al., 2001; Semenza, 2007).”
• Energy Metabolism in Human Pluripotent Stem Cells and Their Differentiated Counterparts (2011, background): “It is known that glycolysis and OXPHOS function in a coordinated fashion, and that the former generates 18 times more ATP per molecule of oxidized glucose than the former [25].”
• Hypoxia-induced angiogenesis: good and evil. (2011, background): “Therefore, a constant O 2 supply, maintained by the vascular system in mammals, is critical for proper tissue development, homeostasis, and function.(1) Tissue oxygenation is governed by a balance between O 2 supply, delivered by the vasculature, and demand generated by metabolic outputs of tissues.”
• Hypoxia-Inducible Factor 1α Induces Fibrosis and Insulin Resistance in White Adipose Tissue (2009, background): “Tumors can divert their pyruvate metabolism away from the mitochondrial electron transport chain toward an anaerobic conversion into lactate through a process that is largely mediated by HIF1 (40).”