Signaling networks guiding epithelial–mesenchymal transitions during embryogenesis and cancer progression
By A. Moustakas, C. Heldin. Cancer Science, 2007
834 citations recorded by the source corpus.
Subfields: Cell Biology, Molecular Biology, Oncology
View Paper: https://www.semanticscholar.org/paper/e0d6c019f2c3211d4a3bd6a2c46d954600f6fbb5
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Cell Biology
- Angeliki Voulgari
- H. Ikushima
- G. Moreno-Bueno
- A. Cano
- F. Portillo
- Louis Vermeulen
- K. Miyazono
- R. Derynck
In Molecular Biology
- R. Derynck
- Samy Lamouille
- A. Cano
- G. Moreno-Bueno
- K. Miyazono
- Angeliki Voulgari
- A. Pintzas
- Yoko Katsuno
In Oncology
- R. Derynck
- A. Cano
- G. Moreno-Bueno
- Samy Lamouille
- Angeliki Voulgari
- H. Ikushima
- F. Portillo
- Yuxin Lin
Citations in the corpus
- Transcriptional regulation of cell polarity in EMT and cancer (2008, background): “…(reviewed by Zavadil and Bottinger, 2005), leading to the upregulation of several EMT inducers, including SNAI1/SNAI2, ZEB1, Twist and the Id factors through Smad-dependent and Smad-independent pathways (Peinado et al., 2003; Kondo et al., 2004; Thuault et al., 2006; Moustakas and Heldin, 2007).”
- TGF-&bgr; signaling and epithelial–mesenchymal transition in cancer progression (2013, background): “TGF-b-induced non-Smad signaling also promotes the EMT program [7,20,21] (Fig.”
- Wnt activity defines colon cancer stem cells and is regulated by the microenvironment (2010, background): “Moreover, in normal development Wnt signals are crucially tethered to the induction of EM”
- Tumor-associated macrophages in tumor metastasis: biological roles and clinical therapeutic applications (2019, background): “During EMT process, tumor cells lose cell-cell junctions and apical-basal polarity as a result of E-cadherin repression and acquire a motile mesenchymal cell phenotype [77, 78].”
- TGFβ signalling: a complex web in cancer progression (2010, result): “TGFβ was first described as an inducer of EMT in normal mammary epithelial cells, and several subsequent studies established crucial roles of TGFβ-induced EMT in tumour progressio”
- Epithelial-mesenchymal transition in cancer metastasis: mechanisms, markers and strategies to overcome drug resistance in the clinic. (2009, background): “extensively studied effect, is that of the transforming growth factor beta (TGFβ) acting via the Smad proteins or the ERK and PI3 K signalling pathways [111,122,123].”