Glucose Uptake Is Limiting in T Cell Activation and Requires CD28-Mediated Akt-Dependent and Independent Pathways1

By S. Jacobs, Catherine E. Herman, Nancie J. MacIver, J. Wofford, Heather L. Wieman, J. Hammen, J. Rathmell. Journal of Immunology, 2008

814 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/e0346105465538d60087a96031933167fd56d73f

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

In Molecular Biology

Citations in the corpus

T cell metabolism drives immunity (2015, background): “When deprived of glucose, CD8 T cells display defects in functional capacity with reduced IFN-, granzyme, and perforin production (Cham and Gajewski, 2005; Cham et al., 2008; Jacobs et al., 2008).”
Unraveling the Complex Interplay Between T Cell Metabolism and Function (2018, background): “A critical step in the activation and differentiation of T cells is the increase in the glucose transporter Glut1 expression and trafficking to the cell surface (74).”
Metabolic competition in the tumor microenvironment is a driver of cancer progression (2015, background): “This view is consistent with the idea that T cell activation and costimulation remodel metabolism, endowing the cell with features that allow it to efficiently compete for nutrients, e.g., Glut1 expression (Jacobs et al., 2008).”
Cutting Edge: Distinct Glycolytic and Lipid Oxidative Metabolic Programs Are Essential for Effector and Regulatory CD4+ T Cell Subsets (2011, background): “1G) and Ig deposition in the kidneys (3).”
Memory CD8+ T cells use cell intrinsic lipolysis to support the metabolic programming necessary for development (2014, background): “Importantly, although the data showing that memory T and Tn cells acquire more 2- NBDG than Teff are surprising, they do not argue against a role for glucose and glycolysis in Teff cell proliferation or effector function (Chang et al., 2013; Fox et al., 2005; Jacobs et al., 2008; Wang et al., 2011).”
Normalization of CD4+ T Cell Metabolism Reverses Lupus (2015, background): “Glycolysis is critical for T cell effector functions, and increased glycolysis leads to autoimmunity (13, 17).”
The Glucose Transporter Glut1 is Selectively Essential for CD4 T Cell Activation and Effector Function (2014, neutral): “In vitro-stimulated murine and human T cells express high levels of Glut1 (Slc2a1) (Frauwirth et al., 2002; Jacobs et al., 2008), and Teff cells maintain levels of Glut1 higher than those of Treg (Michalek et al., 2011a).”
Metabolic Regulation of T Lymphocytes (2013, background): “Glut1transgenic T cells were readily activated and showed increased proliferation and cytokine secretion (23).”
The energy sensor AMPK regulates T cell metabolic adaptation and effector responses in vivo. (2015, background): “Limiting glucose or glutamine in culture medium decreases the activation of naive T cells and subsequent T cell proliferation (Ardawi and Newsholme, 1983; Brand, 1985; Carr et al., 2010; Jacobs et al., 2008; Wang et al., 2011).”
Dietary Fiber Confers Protection against Flu by Shaping Ly6c− Patrolling Monocyte Hematopoiesis and CD8+ T Cell Metabolism (2018, background): “The functional capacity of CD8+ T cells is largely dependent on glucose availability and uptake (Cham et al., 2008; Jacobs et al., 2008).”
Distinct Regulation of Th17 and Th1 Cell Differentiation by Glutaminase-Dependent Metabolism (2018, background): “, 2013) and specific effector functions, including transcription and translation of interferon-g (IFNg) (Chang et al., 2013; Jacobs et al., 2008; Peng et al., 2016) in activated Th1 CD4 T cells and CD8 T cells.”