Plasmacytoid dendritic cells sense self-DNA coupled with antimicrobial peptide

By R. Lande, Josh Gregorio, V. Facchinetti, Bithi Chatterjee, Yi-hong Wang, B. Homey, W. Cao, Yu Wang, Bing Su, Frank O. Nestle and 5 more. Nature, 2007

1,876 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/e0014b702f3ce87bd998053d3be33259a21d21ca

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In Immunology

1. Shizuo Akira
2. Taro Kawai
3. Zhijian J. Chen
4. O. Takeuchi
5. G. Barber
6. R. Medzhitov
7. Katherine A. Fitzgerald
8. Yong‐jun Liu

Citations in the corpus

• The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors (2010, background): “LL37 forms aggregates with self DNA and RNA released by necrotic cells, and these aggregates are endocytosed and retained in the early endosomes of pDCs, where they activate TLR9 and TLR7, respectivel”
• DAMPening Inflammation by Modulating TLR Signalling (2010, background): “TLR7, 8, and TLR9 expressed by pDCs respond to self-RNA and -DNA respectively when coupled with the endogenous antimicrobial peptide LL37 [91, 92].”
• Plasmacytoid dendritic cells: sensing nucleic acids in viral infection and autoimmune diseases (2008, background): “In psoriasis, a common autoimmune disease of the skin, pDCs sense self DNA that is released locally following skin injur”
• The Multifaceted Functions of Neutrophils (2013, background): “LL-37 can also potentiate functions of other immune cells, such as DCs (111).”
• STING-Dependent Cytosolic DNA Sensing Mediates Innate Immune Recognition of Immunogenic Tumors (2014, background): “One candidatemechanism of DNA transfer is through binding to the antimicrobial peptide LL37 (Lande et al., 2007).”
• Role of intestinal microbiota and metabolites on gut homeostasis and human diseases (2017, background): “The resultant LL37-DNA complex is found to promote the endocytosis pathway and to sustain TLR9 activation by modifying the interaction with DNA [30].”
• Production of interleukin 22 but not interleukin 17 by a subset of human skin-homing memory T cells (2009, background): “, where they are stimulated by self DNA in complex with antimicrobial peptide”
• Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis (2010, background): “This fact may further exacerbate the autoimmune response and form a vicious cycle that leads to the formation of immune complexes, which are known to induce Ab production (36, 39).”
• Self-RNA–antimicrobial peptide complexes activate human dendritic cells through TLR7 and TLR8 (2009, methodology): “Skin samples used were 6-mm punch biopsies previously described (Lande et al., 2007).”
• STING-dependent Cytosolic DNA Sensing Promotes Radiation-induced Type I interferon-dependent Antitumor Immunity in Immunogenic Tumors (2014, background): “DNA binding proteins such as LL37 are prevalent in neutrophil extracellular traps (NETs) and believed to enhance cytoplasmic delivery of DNA (Diana et al., 2013; Lande et al., 2007).”
• Trex1 prevents cell-intrinsic initiation of autoimmunity (2008, neutral): “A complex of extracellular DNA and the antimicrobial peptide LL37 activates TLR9-dependent IFN production by plasmacytoid dendritic cells (pDCs) in human psoriasis (Lande et al., 2007).”
• Mast cells and neutrophils release IL-17 through extracellular trap formation in psoriasis (2011, neutral): “IFN-a release from plasmacytoid dendritic cells (58).”