Impairment of neutrophil extracellular trap degradation is associated with lupus nephritis

By Abdul Hakkim, B. Fürnrohr, K. Amann, B. Laube, U. Abed, V. Brinkmann, M. Herrmann, R. Voll, Arturo Zychlinsky. Proceedings of the National Academy of Sciences of the United States of America, 2010

1,456 citations recorded by the source corpus.

Subfields: Immunology, Immunology and Allergy, Pulmonary and Respiratory Medicine

View Paper: https://www.semanticscholar.org/paper/49e9136bc724165085418fff09932b84d6332344

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. P. Kubes
2. Arturo Zychlinsky
3. V. Brinkmann
4. V. Papayannopoulos
5. N. Borregaard
6. A. Mócsai
7. Jacques Banchereau
8. K. Martinod

In Immunology and Allergy

1. Arturo Zychlinsky
2. Yong‐jun Liu
3. A. Mócsai
4. Zena Werb
5. N. Borregaard
6. P. Kubes

In Pulmonary and Respiratory Medicine

1. P. Kubes
2. Arturo Zychlinsky
3. V. Brinkmann
4. A. Mócsai
5. V. Papayannopoulos

Citations in the corpus

• Neutrophils: Between Host Defence, Immune Modulation, and Tissue Injury (2015, background): “Several chronic inflammatory disease conditions are characterized by a sustained influx of neutrophils, such as CF, chronic obstructive pulmonary disease, rheumatoid arthritis, nephritis, SLE, and cardiovascular diseases.”
• Netting neutrophils induce endothelial damage, infiltrate tissues and expose immunostimulatory molecules in systemic lupus erythematosus (2011, background): “Further, impaired NET degradation has been identified in a subset of SLE patients, secondary to DNase1 inhibitors and anti-NET Abs that prevent DNase1 access to NETs (2).”
• Diverse stimuli engage different neutrophil extracellular trap pathways (2017, background): “…(SLE) and vasculitis also show a very strong NET phenotype with regard the presence of autoantibodies against proteins readily released from neutrophils in the process of NETosis such as anti-dsDNA and anti-neutrophil cytoplasmic autoantibodies (Hakkim et al., 2010; Kessenbrock et al., 2009).”
• NETosis: how vital is it? (2013, background): “Finally, they revealed that SLE nondegraders were at higher risk of developing nephritis and had pathological evidence of NET deposition within the kidney.(121) Further investigation has revealed that subsets of neutrophils, expanded in lupus patients, are prone to NETosis, potentially due to overex”
• Platelets induce neutrophil extracellular traps in transfusion-related acute lung injury. (2012, background): “In vitro studies have demonstrated that NETs may be dismantled using DNase1, which helps to untangle the web of extracellular chromatin (31).”
• A Myeloperoxidase-Containing Complex Regulates Neutrophil Elastase Release and Actin Dynamics during NETosis (2014, neutral): “…of NET degradation is linked to several diseases, including cystic fibrosis, preeclampsia, autoimmunity, and vascular diseases (Garcia-Romo et al., 2011; Hakkim et al., 2010; Kessen-brock et al., 2009; Khandpur et al., 2013; Lande et al., 2011; Papayannopoulos et al., 2011; Villanueva et al., 2011).”
• The Multifaceted Functions of Neutrophils (2013, background): “Excessive NET formation is linked to various neutrophilmediated pathologies, including vasculitis (131), sepsis (118), and systemic lupus erythematosus (SLE) nephritis (132).”
• Neutrophil Extracellular Traps Directly Induce Epithelial and Endothelial Cell Death: A Predominant Role of Histones (2012, background): “as preeclampsia, small-vessel vasculitis and systemic lupus erythematosus [26,28,29,31,60,61].”