ADAM10 is the physiologically relevant, constitutive α‐secretase of the amyloid precursor protein in primary neurons

By Peer-Hendrik Kuhn, Huanhuan Wang, B. Dislich, A. Colombo, U. Zeitschel, J. Ellwart, E. Kremmer, S. Roßner, S. Lichtenthaler. EMBO Journal, 2010

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APP processing in Alzheimer's disease (2011, background): “tion [49], implying that ADAM9 is involved only in regulated a-cleavage.”
Trafficking and proteolytic processing of APP. (2012, background): “Lowering cholesterol levels in cultured cells stimulates a-secretase cleavage of APP through mechanisms involving impaired APP endocytosis and increased steadystate levels of ADAM10 (Kojro et al. 2001).”
Alzheimer's disease risk genes and mechanisms of disease pathogenesis (2014, positive): “org/journ in ADAM10, the major α-secretase involved in shedding of the APP ectodomain (30), cosegregate in seven LOAD families (8,31).”
Alzheimer's disease. (2011, background): “…(12 residues amino-terminal to the transmembrane domain) and is affected by one of the a-secretases, which are members of the ADAM family of membrane-anchored metalloproteases (Sisodia Cite this article as Cold Spring Harb Perspect Biol 2011;3:a004457 3 1992; Buxbaum et al. 1998; Kuhn et al. 2010).”