Alzheimer's disease.

By D. Selkoe. Cold Spring Harbor Perspectives in Biology, 2011

22,756 citations recorded by the source corpus.

Subfields: Molecular Biology, Pharmacology, Physiology

View Paper: https://www.semanticscholar.org/paper/40737e336eb476d224a305b87fefc6bac76c3573

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Citations in the corpus

Microglia in Neurological Diseases: A Road Map to Brain-Disease Dependent-Inflammatory Response (2018, background): “The production and release of inflammatory mediators such as cytokines, ROS and RNS seem to be a common feature linked to microglial response, which is tightly related to neurological disorders where protein homeostasis is imbalanced, such as PD, AD and FTD.”
The Many Faces of Tau (2011, background): “Of the numerous tau kinases implicated in AD pathogenesis, the most widely studied are GSK-3b, CDK5, MARK, and MAPK (Augustinack et al., 2002; Microtubule stabilization/ tau phosphorylation NAP, AL-108 MCI 120 12 weeks Phase II Completed, not yet published PSP 300 52 weeks Phase II/III Recruiting…”
Adherence to a Mediterranean diet, cognitive decline, and risk of dementia. (2009, background): “dative stress, inflammation, and vascular disease, which also participate in the pathophysiology of neurodegenerative disease.(30,31) Individuals with higher adherence to a Mediterranean diet have been shown to have higher plasma concentrations of some presumed beneficial biomarkers.”
The Gut Microbiota and Alzheimer’s Disease (2017, neutral): “Pathologically, AD is characterized by the extracellular deposition of amyloid-(cid:2) peptides (A (cid:2) ) in senile plaques and the intracellular accumulation of hyper-phosphorylated tau that forms neuroﬁbrillary tangles (for review, see [32]).”
Deep learning of joint myelin and T1w MRI features in normal-appearing brain tissue to distinguish between multiple sclerosis patients and healthy controls (2017, positive): “We extract discriminative candidate patches on normal-appearing brain tissue from the myelin and T1w images in the MNI152 template space using a voxel-wise t-test to determine the statistical significance of the group difference between MS and NC images, as similarly done in previous studies (Suk et”
Functional morphology of the blood-brain barrier in health and disease (2018, background): “Alzheimer’s disease (AD) is a chronic neurodegenerative disorder characterised by neuronal degeneration, gliosis, and amyloid beta (Aβ) accumulation, leading to cerebral amyloid angiopathy (CAA), senile plaque formation and the development of neurofibrillary tangles containing hyperphosphorylated ne”
The neuropathological diagnosis of Alzheimer’s disease (2019, background): “Capillary CAA is also linked to APOE4 and a variant (C766T (rs1799986)) in the LDL receptor related protein 1 (LRP-1), a receptor for apolipoproteins, which suggests that capillary CAA my also represent a subtype of AD [105, 106].”
Blood-based biomarkers for Alzheimer's disease: towards clinical implementation. (2021, positive): “1,4,5 A meta-analysis published in 2016 showed no differences in plasma concentrations of Aβ 1–42 and Aβ 1–40 in individuals with Alzheimer’s disease compared with controls.”