AMP-activated/SNF1 protein kinases: conserved guardians of cellular energy

By D. Hardie. Nature reviews. Molecular cell biology, 2007

2,306 citations recorded by the source corpus.

Subfields: Molecular Biology, Plant Science, Surgery

View Paper: https://www.semanticscholar.org/paper/df5943ead4981e8989367cc717f248c463efa5ad

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Molecular Biology

1. David M. Sabatini
2. D. Hardie
3. R. Shaw
4. K. Guan
5. M. Laplante
6. D. Klionsky
7. Craig B. Thompson
8. G. Steinberg

In Plant Science

1. R. Shaw
2. David M. Sabatini
3. Craig B. Thompson
4. Maria M. Mihaylova
5. G. Steinberg
6. Bruce E. Kemp
7. D. Hardie
8. F. Rolland

In Surgery

1. D. Hardie
2. R. Shaw
3. David M. Sabatini
4. K. Guan
5. G. Steinberg
6. Bruce E. Kemp
7. S. Hawley
8. Fiona A. Ross

Citations in the corpus

• Sugar signals and molecular networks controlling plant growth. (2010, background): “These conserved heterotrimeric kinases are crucially important regulators of metabolism and energy homeostasis [39–41].”
• Cancer cell metabolism: Warburg and beyond. (2008, background): “It is well established that AMP-kinase senses the AMP/ATP ratio (reviewed in Hardie, 2007), whereas mTOR (the mammalian target of rapamycin) senses cellular amino acid concentrations (Kim et al., 2008; Sancak et al., 2008).”
• Role of AMPK-mTOR-Ulk1/2 in the Regulation of Autophagy: Cross Talk, Shortcuts, and Feedbacks (2011, background): “key enzymes of the lipid anabolism (30).”
• With TOR less is more: a key role for the conserved nutrient sensing TOR pathway in aging (2010, neutral): “A drop in the cell’s energy content is reflected in the rise of the AMP/ATP ratio and triggers AMP-dependent activation of AMP-dependent kinase (AMPK) (Hardie, 2007).”
• Hooked on fat: the role of lipid synthesis in cancer metabolism and tumour development (2013, background): “Conversely, ACC and HMGCR are targets of AMPK, which phosphorylates and inhibits these enzymes in response to low cellular energy levels (Carling et al., 1989) (reviewed by Hardie, 2007).”
• Crosstalk between apoptosis, necrosis and autophagy. (2013, background): “AMPK(AMP-activatedkinase) functions as a cellular energy biosensor, activated upon ATP depletion [134].”
• Use of Cells Expressing γ Subunit Variants to Identify Diverse Mechanisms of AMPK Activation (2010, background): “Once activated, AMPK switches on catabolic pathways that generate ATP, while switching off ATP-requiring processes not essential for short-term cell survival, including cell growth and proliferation (Hardie, 2007).”
• Metabolic Regulation of T Lymphocytes (2013, background): “Whereas mTORC1 promotes anabolic processes to stimulate cell growth, AMPK is a well-known energy regulator that maximizes energy generation by promoting catabolic pathways (69).”
• LKB1 and AMPK control of mTOR signalling and growth (2009, background): “The ability of metformin and other AMPK-activating drugs to act as insulin sensitizers is well documented (Towler & Hardie 2007), and one explanation for that effect is that by 70 2009 The Author Journal compilation 2009 Scandinavian Physiological Society, doi: 10.1111/j.1748-1716.2009.01972.x AMPK…”
• AMPK - a nutrient and energy sensor that maintains energy homeostasis (2012, background): “However, the principal energy sensor in most eukaryotic cells seems to be AMP-activated protein kinase (AMPK”