Hooked on fat: the role of lipid synthesis in cancer metabolism and tumour development

By F. Baenke, B. Peck, H. Miess, A. Schulze. Disease Models & Mechanisms, 2013

732 citations recorded by the source corpus.

An increased rate of lipid synthesis in cancerous tissues has long been recognised as an important aspect of the rewired metabolism of transformed cells. However, the contribution of lipids to cellular transformation, tumour development and tumour progression, as well as their potential role in facilitating the spread of cancerous cells to secondary sites, are not yet fully understood. In this article, we review the recent findings that support the importance of lipid synthesis and metabolism in tumorigenesis. Specifically, we explore the role of aberrant lipid biosynthesis in cancer cell migration and invasion, and in the induction of tumour angiogenesis. These processes are crucial for the dissemination of tumour cells and formation of metastases, which constitute the main cause of cancer mortality.

Subfields: Biochemistry, Cancer Research

View Paper: https://www.semanticscholar.org/paper/649d46b083285415ac36decc01d04b9d4db36846

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Biochemistry

1. Nikos Koundouros
2. G. Poulogiannis
3. A. Schulze

In Cancer Research

1. Eyal Gottlieb
2. G. Poulogiannis
3. Nikos Koundouros
4. Adrian L. Harris
5. A. Schulze
6. G. Semenza

Citations in the corpus

• Acetyl-CoA Synthetase 2 Promotes Acetate Utilization and Maintains Cancer Cell Growth under Metabolic Stress (2015, background): “Cancer Cell 27, 57–71, January 12, 2015 ª2015 The Authors 57 for biomass production required for growth and survival under unfavorable conditions (Baenke et al., 2013).”
• Membrane Lipid Composition: Effect on Membrane and Organelle Structure, Function and Compartmentalization and Therapeutic Avenues (2019, background): “Also, the ordinary expression of SREBPs is needed to maintain the apical surface of normal epithelial cells and is lost in many cancers (reviewed in [135])”
• Reprogramming of fatty acid metabolism in cancer (2019, background): “2).12,13 This is largely achieved through β-oxidation of stored lipids, leading to the production of acetyl-CoA through oxidative degradation of FAs.14,15 The acetylCoA produced from each round of β-oxidation can subsequently enter the tricarboxylic acid (TCA) cycle to generate NADH and FADH2 for th”