Estrogen deficiency induces bone loss by enhancing T-cell production of TNF-alpha.
By S. Cenci, M. Weitzmann, C. Roggia, N. Namba, D. Novack, Jessica Woodring, R. Pacifici. Journal of Clinical Investigation, 2000
697 citations recorded by the source corpus.
Subfields: Molecular Biology, Oncology, Pharmacology
View Paper: https://www.semanticscholar.org/paper/df205db3889bb72a2e3bc4f4d5d1188b0742e8e3
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Citations in the corpus
- Sex steroids and bone. (2002, background): “, 1999) or increasing the number of TNF-synthesizing lymphocytes (Cenci et al., 2000).”
- Disorders of bone remodeling. (2011, background): “First, nude mice, which lack T lymphocytes, are protected from ovariectomy-induced bone loss (74), which demonstrates that circulating T cells, not monocytes, are the major source of estrogen-regulated TNF.”
- Coupling the activities of bone formation and resorption: a multitude of signals within the basic multicellular unit. (2014, result): “B-lymphocytes have also been shown to inhibit osteoclast formation in vitro in a manner inhibited by a TGFb-neutralizing antibody.(118) In contrast to these studies, intramembranous bone formation in the process of fracture healing does not appear to be impaired in B-lymphocytedeficient mice.”
- Estrogen and the Skeleton (2012, positive): “Pacifici and colleagues (45, 46) have proposed that the rapid bone loss following loss of estrogen is due to an expansion of T cells leading to increased TNF-α levels in the bone microenvironment, thereby indirectly enhancing osteoclastogenesis.”
- The gut microbiota regulates bone mass in mice (2012, background): “Osteoclastogenesis can also be regulated by cytokines under physiological conditions, and T-cell–produced TNFa is thought to play a role in ovx-induced bone loss.((19,57)) GF mice have low numbers of TNFa-producing CD4þ T cells in colon compared with CONV-R mice.”
- Role of RANK ligand in mediating increased bone resorption in early postmenopausal women. (2003, background): “These cytokines increase bone resorption mainly by increasing the pool size of preosteoclasts in bone marrow (1, 3, 4); however, MCSF also enhances fusion of preosteoclasts to form osteoclasts (5) and, recently, direct effects of TNF-α on osteoclasts have been demonstrated (6, 7).”
- Genetic regulation of osteoclast development and function (2003, background): “Nude mice that lack T cells do not lose bone or develop the osteoporosis that occurs in wild-type animals following OOPHORECTOMY”
- Osteal Tissue Macrophages Are Intercalated throughout Human and Mouse Bone Lining Tissues and Regulate Osteoblast Function In Vitro and In Vivo1 (2008, background): “Additionally, macrophages were found at sites of pathological bone destruction (36) and contributed to systemic mechanisms in an animal model of osteoporosis (37).”
- Osteoimmunology: interplay between the immune system and bone metabolism. (2006, background): “Interestingly, activated T cells may cause rapid bone loss under conditions of estrogen deficiency by enhancing TNF-α production (51).”
- Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells (2015, background): “The secretory activity of bone lining cells depends on the bone physiological status, whereby these cells can reacquire their secretory activity, enhancing their size and adopting a cuboidal appearance [52].”