The gut microbiota regulates bone mass in mice

By K. Sjögren, C. Engdahl, P. Henning, U. Lerner, V. Tremaroli, M. Lagerquist, F. Bäckhed, C. Ohlsson. Journal of Bone and Mineral Research, 2012

753 citations recorded by the source corpus.

The gut microbiota modulates host metabolism and development of immune status. Here we show that the gut microbiota is also a major regulator of bone mass in mice. Germ‐free (GF) mice exhibit increased bone mass associated with reduced number of osteoclasts per bone surface compared with conventionally raised (CONV‐R) mice. Colonization of GF mice with a normal gut microbiota normalizes bone mass. Furthermore, GF mice have decreased frequency of CD4+ T cells and CD11b+/GR 1 osteoclast precursor cells in bone marrow, which could be normalized by colonization. GF mice exhibited reduced expression of inflammatory cytokines in bone and bone marrow compared with CONV‐R mice. In summary, the gut microbiota regulates bone mass in mice, and we provide evidence for a mechanism involving altered immune status in bone and thereby affected osteoclast‐mediated bone resorption. Further studies are required to evaluate the gut microbiota as a novel therapeutic target for osteoporosis. © 2012 American Society for Bone and Mineral Research.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/5ec5ee6e1be47e9d50b4d456294d1e158bc4fc73

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Citations in the corpus

Gut microbiota induce IGF-1 and promote bone formation and growth (2016, background): “We found that colonization of the adult mouse gut with SPF microbiota acutely increased bone resorption and reduced bone mass, which confirms earlier findings (13).”
Gut bacteria that rescue growth impairments transmitted by immature microbiota from undernourished children (2016, result): “Although our sample size was small, these results provide additional evidence for microbiota-dependent regulation of bone morphology (17), with the effects being influenced by the age and nutritional status of the”
The National Osteoporosis Foundation’s position statement on peak bone mass development and lifestyle factors: a systematic review and implementation recommendations (2016, background): “The role of the gut microbiome in regulating bone mass was recently demonstrated using a germ-free mouse model [280].”
Gut microbes promote colonic serotonin production through an effect of short‐chain fatty acids on enterochromaffin cells (2015, background): “Female GFmice have significantly lower colonic expression of Tph1 mRNA compared with CR C57Bl6/J mice (39); however, the specific impact of”