Estrogen and the Skeleton
By S. Khosla, M. Oursler, D. Monroe. Trends in endocrinology and metabolism, 2012
838 citations recorded by the source corpus.
Estrogen is the major hormonal regulator of bone metabolism in women and men. Therefore, there is considerable interest in unraveling the pathways by which estrogen exerts its protective effects on bone. While the major consequence of the loss of estrogen is an increase in bone resorption, estrogen deficiency is associated with a gap between bone resorption and formation, indicating that estrogen is also important for maintaining bone formation at the cellular level. Direct estrogen effects on osteocytes, osteoclasts, and osteoblasts lead to inhibition of bone remodeling, decreased bone resorption, and maintenance of bone formation, respectively. Estrogen also modulates osteoblast/osteocyte and T-cell regulation of osteoclasts. Unraveling these pleiotropic effects of estrogen may lead to new approaches to prevent and treat osteoporosis.
Subfields: Molecular Biology, Oncology, Orthopedics and Sports Medicine
View Paper: https://www.semanticscholar.org/paper/5b63e7da407ae589a78445924f7a13986f522dbe
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In Molecular Biology
Citations in the corpus
- Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells (2015, background): “Estrogen plays crucial roles for bone tissue homeostasis; the decrease in estrogen level at menopause is the main cause of bone loss and osteoporosis [16].”