Mesocorticolimbic Circuits are Impaired in Chronic Cocaine Users as Demonstrated by Resting State Functional Connectivity
By Hong Gu, Betty Jo Salmeron, Thomas J. Ross, Xiujuan Geng, Wang Zhan, Elliot A. Stein, Yihong Yang. NeuroImage, 2010
302 citations recorded by the source corpus.
Preclinical models have consistently demonstrated the importance of the mesocorticolimbic (MCL) brain reward system in drug dependence, with critical molecular and cellular neuroadaptations identified within these structures following chronic cocaine administration. Cocaine dependent individuals manifest alterations in reward functioning that may relate to changes induced by cocaine or to pre-existing differences related to vulnerability to addiction. The circuit level manifestations of these drug-induced plastic changes and predispositions to drug dependence are poorly understood in preclinical models and virtually unknown in human drug dependence. Using whole-brain resting-state fMRI connectivity analysis with seed voxels placed within individual nodes of the MCL system, we report network-specific functional connectivity strength decreases in cocaine users within distinct circuits of the system, including between ventral tegmental area (VTA) and a region encompassing thalamus/lentiform nucleus/nucleus accumbens, between amygdala and medial prefrontal cortex (mPFC), and between hippocampus and dorsal mPFC. Further, regression analysis on regions showing significant functional connectivity decrease in chronic cocaine users revealed that the circuit strength between VTA and thalamus/lentiform nucleus/nucleus accumbens was negatively correlated with years of cocaine use. This is the first evidence of circuit-related changes in human cocaine dependence and is consistent with the range of cognitive and behavioral disruptions seen in cocaine dependence. As potential circuit level biomarkers of cocaine dependence, these circuit alterations may be usefully applied in treatment development and monitoring treatment outcome.
Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience
View Paper: https://www.semanticscholar.org/paper/383cba6a0a0abc2d29a3660fa9a83ed27ae99b52
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In Cellular and Molecular Neuroscience
In Cognitive Neuroscience
Citations in the corpus
- Resting state functional connectivity in addiction: Lessons learned and a road ahead (2012, background): “Alterations in rsFC strength between ventral striatum and various subcortical and cortical regions have been observed when comparing cocaine (Gu et al., 2010; Tomasi et al., 2010; Wilcox et al., 2011), prescription opioid (Upadhyay et al.”