PUMA induces the rapid apoptosis of colorectal cancer cells.
By Jian Yu, Lin Zhang, P. Hwang, Kenneth W. Kinzler, Bert Vogelstein. Molecules and Cells, 2001
1,370 citations recorded by the source corpus.
Subfields: Artificial Intelligence, Education, Information Systems
View Paper: https://www.semanticscholar.org/paper/de378cdfb4b0354964774abcc5cf77181064432c
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Citations in the corpus
- Cell Death Signaling. (2015, background): “…Jeffers et al. 2003; Villunger et al. 2003; You et al. 2006; Ekoff et al. 2007 DNA damage Transcription p53 Apoptosis Nakano and Vousden 2001; Yu et al. 2001; Jeffers et al. 2003; Villunger et al. 2003 DNA damage or ER stress Transcription p63 Apoptosis Pyati et al. 2011; Kerr et al.…”
- The expanding role of mitochondria in apoptosis. (2001, background): “Two proapoptotic gene products, Noxa and Puma, were identified recently as BH3-only members of the Bcl-2 family that are induced in a p53-dependent manner in primary mouse cells exposed to X-ray irradiation (E. Oda et al. 2000; Nakano and Vousden 2001; Yu et al. 2001).”
- Bcl-2-family proteins and the role of mitochondria in apoptosis. (2003, background): “Noxa [46] and Puma [47,48], for example, are upregulated following p53 activation in certain cell types, whereas Hrk/DP5 [49–51] is transcriptionally activated in neuronal cell death induced by NGF withdrawal or exposure to amyloid b.”
- Mitochondrial dysfunction and oxidative stress in neurodegenerative diseases (2006, positive): “In response to genotoxic injury, p53 activates mitochondrial pathway apoptosis by increasing transcription of the pro-apoptotic BH3-only Bcl-2 family members such as PUM”
- Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies (2006, background): “Interestingly, it seems that most, and probably all, intrinsic death signals activate both activator and inactivator BH3s simultaneously: DNA damage upregulates PUMA and NOX”
- Bax and Bak can localize to the endoplasmic reticulum to initiate apoptosis (2003, background): “…such as tBid, Bim, Noxa, and Puma, at mitochondria when apoptosis is triggered has suggested that the activation of Bax/Bak by BH3-only proteins may take place at this site (Li et al., 1998; Luo et al., 1998; Puthalakath et al., 1999; Oda et al., 2000; Nakano and Vousden, 2001; Yu et al., 2001).”