Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies

By Hyungjin Kim, Mubina Rafiuddin-Shah, Ho-Chou Tu, John R. Jeffers, G. Zambetti, J. Hsieh, E. Cheng. Nature Cell Biology, 2006

918 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/8e7a39cbff004d023b39496af1039709a39baa0d

How researchers see this paper

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In Immunology

1. Douglas R. Green
2. Suzanne Cory
3. P. Ney
4. Jerry M. Adams
5. Ji Zhang
6. F. Llambi
7. Guido Kroemer
8. J. Wells

In Molecular Biology

1. Douglas R. Green
2. Jerry M. Adams
3. Suzanne Cory
4. J. Chipuk
5. H. Ahsan
6. F. Llambi
7. A. Letai
8. Angelina V. Vaseva

Citations in the corpus

• Control of mitochondrial apoptosis by the Bcl-2 family (2009, background): “In fact, there are data that support the role of Puma, p53 and heat as activators of Bax and Bak (Chipuk et al., 2004; Kim et al., 2006; Pagliari et al., 2005), and possibly others remain undiscovered.”
• Mechanisms of action of Bcl-2 family proteins. (2013, background): “The antiapoptotic proteins bind to both the activator and the sensitizer BH3 proteins, but are unable to complex with Bax and Bak (Kim et al. 2006).”
• Apoptosis and Molecular Targeting Therapy in Cancer (2014, background): “, Bad, Bik, Bmf, Hrk, Noxa, and Puma), which do not activate Bax/Bak directly but instead neutralize antiapoptotic proteins [29, 30].”
• Role of Bcl-2 family proteins and caspases in the regulation of apoptosis (2011, background): “However, it is likely that additional factors other than Bid and Bim can act as activators such as Puma, p53, and heat as activators of Bax and Bak [58–60], and possibly others.”
• Membrane binding by tBid initiates an ordered series of events culminating in membrane permeabilization by Bax. (2008, background): “In some systems, activa- 1074 Cell 135, 1074–1084, December 12, 2008 ª2008 Elsevier Inc. tion of Bax for MOMP depends on proapoptotic proteins like PUMA, Bim, or a truncated fragment of Bid (tBid) that are similar only in that they contain a BH3 region (Kim et al., 2006).”
• p53 opens the mitochondrial permeability transition pore to trigger necrosis (2012, background): “Bax/Bak DKO cells are deprived of the apoptotic gateway to mediate CytoC release for caspase activation (Kim et al., 2006).”
• The Bcl-2 apoptotic switch in cancer development and therapy (2007, background): “Puma has also been implicated as an activator (Carton et al., 2004; Kim et al., 2006a).”