Membrane blebbing during apoptosis results from caspase-mediated activation of ROCK I

By M. Coleman, Erik Sahai, M. Yeo, M. Bosch, A. Dewar, M. Olson. Nature Cell Biology, 2001

1,346 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/dd95355cf3a42923e61ef336818619bf6ca11ec2

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Citations in the corpus

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018 (2018, background): “(PS) exposure [209, 210], and the formation of apoptotic bodies [211, 212].”
Cell Death Signaling. (2015, background): “…GTPases, thus inducing an aberrant reorganization of the actin cytoskeleton and the characteristic membrane blebbing observed in apoptotic cells (Rudel and Bokoch 1997; Coleman et al. 2001; Sebbagh et al. 2001) (for more details on cytoskeleton-modulating proteins, see Devreotes and Horwitz 2014).”
Biogenesis of extracellular vesicles (EV): exosomes, microvesicles, retrovirus-like vesicles, and apoptotic bodies (2013, positive): “The available data suggest that membrane blebbing is, in part, mediated, by actin-myosin interaction [99, 100] (Fig.”
Focus on Extracellular Vesicles: Introducing the Next Small Big Thing (2016, background): “Although the externalization of PS is scramblase-dependent and ROCK-independent, its subcellular localization during apoptosis is distinctly ROCK-dependent [107,117].”
ROCKs: multifunctional kinases in cell behaviour (2003, background): “This occurs in vivo during apoptosis, when ROCK I is cleaved by CASPASE -3 to give rise to an active kinas”
Gold nanorod assisted near-infrared plasmonic photothermal therapy (PPTT) of squamous cell carcinoma in mice. (2008, result): “Small increases in local temperature are known to result in disruption of nuclear and cytoskeletal assemblies and indeed, previous [44,84] and recent reports [29,72] indicate significant membrane blebbing [85–87] under hyperthermic conditions.”
Germinal-center organization and cellular dynamics. (2007, background): “Studies in several cell types showed that early during apoptosis, caspases can cleave and activate the Rho kinase ROCK-I, in turn causing myosin light-chain kinase activation and inducing the events necessary for plasma-membrane blebbing (Coleman et al., 2001; Sebbagh et al., 2001; Shiratsuchi et al”
Blebs lead the way: how to migrate without lamellipodia (2008, background): “Activation of both pathways has been observed in non-motile blebbing cell”