ROCKs: multifunctional kinases in cell behaviour

By K. Riento, A. Ridley. Nature reviews. Molecular cell biology, 2003

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Multiple targets of miR-302 and miR-372 promote reprogramming of human fibroblasts to induced pluripotent stem cells (2011, background): “Y-27632 (ROCKi) is a small-molecule inhibitor of the RHO-dependent protein kinase ROCK, which acts immediately downstream of RH”
Engulfment of apoptotic cells: signals for a good meal (2007, background): “A RHO-GTP-dependent increase in the kinase activity of ROCK influences the status of myosin light chain (MLC) phosphorylation, and in turn, can promote actomyosin assembly and cell contractilit”
Chemotaxis: signalling the way forward (2004, background): “pl?Q13464">ROCK ), which are both stimulated by chemoattractant receptors; ROCK also inhibits an MLC phosphatas”
The role of the Rho GTPases in neuronal development. (2005, background): “Rho-kinases are serine/ threonine kinases that play several roles in RhoA-induced actin reorganization (Riento and Ridley 2003).”