Differential regulation of antiviral T-cell immunity results in stable CD8+ but declining CD4+ T-cell memory

By D. Homann, L. Teyton, M. Oldstone. Nature Medicine, 2001

684 citations recorded by the source corpus.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/dd5234259447ad74f0dec53cc16151ef81066f4d

How researchers see this paper

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In Immunology

1. Rafi Ahmed
2. E. Wherry
3. S. Kaech
4. V. Appay
5. Y. Belkaid
6. T. Hand
7. D. Sauce
8. A. Schietinger

Citations in the corpus

• Translating innate immunity into immunological memory: implications for vaccine development. (2006, neutral): “However, with CD4+ T cells, there appears to be a decline in antigen-specific memory T cells after an initial immune response to lymphocytic choriomeningitis virus (LCMV) in mice (Homann et al., 2001).”
• Heterogeneity and cell-fate decisions in effector and memory CD8+ T cell differentiation during viral infection. (2007, background): “, 2006), though the attrition of these cells has been documented in some infections (Homann et al., 2001).”
• Role of the Microbiota in Immunity and inflammation (2014, background): “Much like pathogen-specific CD4 T cells, commensal-specific memory T cells declined steadily over time (Hand et al., 2012; Homann et al., 2001; Pepper et al., 2010).”
• Naive CD4(+) T cell frequency varies for different epitopes and predicts repertoire diversity and response magnitude. (2007, background): “…at least for certain peptides, variations in naïve CD4+ T cells population size may account for the observation that the number of T cells generated at the peak of the primary immune response to infection varies for different pMHCII (Busch et al., 1998; Homann et al., 2001; Masopust et al., 2006).”
• Immune activation and inflammation in HIV‐1 infection: causes and consequences (2008, background): “While a large number of T cells ends up dying upon activation, dynamics of activation, expansion and apoptosis seem to differ between CD4+ and CD8+ T cells [47–49].”
• Molecular and functional profiling of memory CD8 T cell differentiation. (2002, background): “…the effector cell pop- cells acquire memory cell properties several weeks after ulation through apoptosis, and generation of a long- virus clearance. lived population of memory cells (Dutton et al., 1998; Homann et al., 2001; Kaech et al., 2002; Murali-Krishna Results and Discussion et al., 1998).”