Oxidative damage to DNA: formation, measurement and biochemical features.

By J. Cadet, T. Douki, D. Gasparutto, J. Ravanat. Mutation research, 2003

687 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/dd4dfeada91073aeea5a803cf8d9acb2755ef942

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Citations in the corpus

The role of double-strand break repair — insights from human genetics (2006, background): “For example, damaged bases, sugar phosphates and/or single-strand breaks (SSBs) might lie close to a DS”
Oxidative stress as a mediator of life history trade-offs: mechanisms, measurements and interpretation. (2009, methodology): “…such as HPLC with mass spectrometry, antibodybased immunoassays, the ARP assay in combination with an ELISA-like assay and the comet assay (single-cell electrophoresis method), are also available (Kow & Dare 2000; Guetens et al. 2002; Cadet et al. 2003; Mateos & Bravo 2007 – also see Table 1).”
A review of the interaction among dietary antioxidants and reactive oxygen species. (2007, methodology): “The reliability of commonly used methods to determine levels of DNA oxidation is imperfect and controversial, leading to questions about the importance of oxidatively damaged DNA in cancer and other pathologies [50]; there has been, however, recent focus on methodological refinement, which have impr”
Autophagy-deficient mice develop multiple liver tumors. (2011, methodology): “We performed immunostaining of 8-hydroxydeoxyguanosine (8-OHdG), which is considered to be an indicator of the oxidative stress (Cadet et al. 2003).”
Oxidative Stress and Antioxidant Defense (2012, background): “8-Oxo-7,8dihydroguanine (8-oxoGua) is the main UVA-mediated DNA oxidation product formed by the oxidation of OH radical, 1-electron oxidants, and singlet oxygen that mainly reacts with guanine.(51) The formation of guanine radical cation in isolated DNA has been shown to efficiently occur through th”
Measurement and Clinical Significance of Biomarkers of Oxidative Stress in Humans (2017, background): “The HO radical can react with all purine and pyrimidine bases, as well as deoxyribose backbone, generating various products, the most common one being 7,8-dihydroxy-8-oxo-2′-deoxyguanosine (8oxodG) [163].”
From molecules to living systems: historical and contemporary issues in oxidative stress and antioxidant ecology (2010, background): “For more comprehensive biochemical descriptions of lipid peroxidation and damage to proteins and nucleic acids, we suggest the following reviews (Porter, Caldwell & Mills 1995; Cadet et al. 2003; Chakravarti & Chakravarti 2007; Halliwell & Gutteridge 2007; Laguerre, Lecomte & Villeneuve 2007; Houben”