Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinases: Structure, Function, and Biochemistry

By R. Visse, Hideaki Nagase. Circulation Research, 2003

1,820 citations recorded by the source corpus.

Subfields: Cancer Research, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/dceb04da5df410040d03c51e34a37d5bac6903a4

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Citations in the corpus

Gelatinase-mediated migration and invasion of cancer cells. (2005, positive): “The cysteine switch mechanism explains why proteases, conformational perturbants such as heat, denaturants or substrate binding, heavy metals and organomercurials, oxidants and alkylating agents are able to activate MMPs (Van Wart and Birkedal-Hansen, 1990; Visse and Nagase, 2003).”
What is Intervertebral Disc Degeneration, and What Causes It? (2006, positive): “Disc cells synthesize their matrix and break down existing matrix by producing and activating degradative enzymes, including matrix metalloproteinases (MMPs) and a disintegrin and metalloproteinase (ADAMS).[14-20] Molecular markers of matrix turnover are naturally most plentiful during growth but us”
Aberrant repair and fibrosis development in skeletal muscle (2011, neutral): “Activation requires proteolytic cleavage of the inactive precursor by either membrane-type (MT)1MMP [105] or plasmin, and cleavage of their corresponding inhibitors [106].”
Extracellular Matrix Communication and Turnover in Cardiac Physiology and Pathology (2015, neutral): “Ithas for anchoring to the proMMP2 and initiating its activation but is not required for MMP inhibitory function of TIMP2 (269,438).”
Forming functional fat: a growing understanding of adipocyte differentiation (2011, neutral): “Cells can regulate the stiffness and composition of their environment by digesting the surrounding ECM with members of the matrix metalloproteinase (MMP) family, which are secreted or membrane-bound zinc-dependent peptidases that cleave ECM components or other secreted factor”
The Airway Epithelium: Soldier in the Fight against Respiratory Viruses (2011, positive): “MMPs play a crucial role in the remodeling of the matrix onto which cells migrate, and many pathways are involved in this process (294).”
A systematic review on silver nanoparticles-induced cytotoxicity: Physicochemical properties and perspectives (2017, positive): “Intracellular oxidative stress causes MMP3to secret a speciﬁc amount of MMP, an extracellular matrix (ECM) digester protease [180,181].”
Structure and function of matrix metalloproteinases and TIMPs. (2006, positive): “Collagenases (MMP-1, MMP-8, MMP-13 and MMP-18 in Xenopus) cleave interstitial collagens I, II and III into characteristic 3/4 and 1/4 fragments but they can digest other ECM molecules and soluble proteins (see [4,23] for detail].”
Matrix metalloproteinases and their inhibitors in vascular remodeling and vascular disease. (2008, neutral): “Matrix metalloproteinases (MMPs) are a family of structurally related, zinc-containing enzymes that degrade the ECM and connective tissue proteins [5,6].”
Focal adhesion kinase: in command and control of cell motility (2005, positive): “Activation of MMPs at the LEADING EDGE of migrating cells functions to promote matrix proteolysis, which leads to the extracellular release of integrin–matrix contacts and thereby facilitates focal contact turnove”