Excitability changes induced in the human motor cortex by weak transcranial direct current stimulation

By Michael A. Nitsche, Walter Paulus. Journal of Physiology, 2000

5,494 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Neurology

View Paper: https://www.semanticscholar.org/paper/dce237e1cd5ef88dea2de7abf0bb4656ae586c15

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Citations in the corpus

Neuroscience and Biobehavioral Reviews Auditory Verbal Hallucinations as Atypical Inner Speech Monitoring, and the Potential of Neurostimulation as a Treatment Option (neutral): “This leads to increased neuronal excitability under the anode, and decreased excitability under the cathode (Nitsche and Paulus, 2000, 2011).”
Pharmacological Modulation of Cortical Excitability Shifts Induced by Transcranial Direct Current Stimulation in Humans (2003, background): “…durations were chosen because 4 s of tDCS results in an excitability change during stimulation without producing after-effects, while a stimulation duration of 9–13 min generates after-effects that last for about 1 h after the end of stimulation (Nitsche & Paulus 2000, 2001; Nitsche et al. 2003a).”
Effects of non-invasive cortical stimulation on skilled motor function in chronic stroke. (2005, background): “…that direct stimulation of a motor cortical representation in rodents elicits cortical reorganization (Nudo et al., 1990), while non-invasive cortical stimulation in humans influences motor cortical excitability (Chen et al., 1997; Pascual-Leone et al., 1998; Nitsche and Paulus, 2000, 2001).”
Direct current stimulation promotes BDNF-dependent synaptic plasticity: Potential implications for motor learning (2010, positive): “Consistent with findings in humans that tDCS polarity is critical in modulating motor cortical excitability (Nitsche and Paulus, 2000) and behavior (Nitsche et al.”
Clinical Research with Transcranial Direct Current Stimulation (tDCS): Challenges and Future Directions (2011, neutral): “In contrast, 10 minutes or more of stimulation can elicit prolonged after-effects, which can be sustained for over an hour.(7,27,39) The exact duration of effects depends on the targeted cortical area and on the type of variable assessed.”
Modeling the current distribution during transcranial direct current stimulation. (2006, background): “The more pertinent issue is whether the reported low current densities can account for the well-established physiological effects of tDCS (see (Priori, 2003) for a review of such effects). The data reviewed by Jefferys (1995) showed that electric fields in the range 2–15 V/m (corresponding to 0.”
Quantitative Review Finds No Evidence of Cognitive Effects in Healthy Populations From Single-session Transcranial Direct Current Stimulation (tDCS). (2015, neutral): “tDCS is most commonly delivered via 2 electrodese 1 anode and 1 cathode e affixed to the scalp overlying cortical regions relevant to the outcome measure of interest [2].”
Optimization of multifocal transcranial current stimulation for weighted cortical pattern targeting from realistic modeling of electric fields (2013, positive): “The neuromodulatory effect of these fields has been confirmed in many laboratories (Antal et al., 2008; Nitsche and Paulus, 2001, 2000; Terney et al., 2008).”
Effects of uniform extracellular DC electric fields on excitability in rat hippocampal slices in vitro (2004, background): “…can be used to study normal neuronal (Jefferys, 1981; Richardson et al. 1984; Bawin et al. 1986; Chan & Nicholson, 1986; Chan et al. 1988; Wong & Stewart, 1992; Jefferys, 1995; Andreasen & Nedergaard, 1996) and cognitive function (Nitsche & Paulus, 2000; Walsh & Cowey, 2000; Liebetanz et al. 2002).”
Post-stroke dementia – a comprehensive review (2017, background): “Non-invasive brain stimulation techniques, including repetitive transcranial magnetic stimulation and transcranial direct current stimulation, have been reported to improve functional status of stroke patients through modulation of the excitability of cortical circuits [117, 118].”
Gyri –precise head model of transcranial DC stimulation: Improved spatial focality using a ring electrode versus conventional rectangular pad (2009, neutral): “005 25-35 cm(2)).(1-4) tDCS modulates cortical function and has been applied to facilitate learning, alter behavioral performance, and improve impaired brain function.”
Inter-individual variability in response to non-invasive brain stimulation paradigms. (2014, neutral): “The most established protocols to increase cortical excitability (by recent citation records) are excitatory paired associative stimulation (PAS) [10], anodal transcranial direct current stimulation (AtDCS) [3] and intermittent theta burst stimulation (iTBS) [11].”
The Role of GABA in Human Motor Learning (2011, positive): “an electrode configuration that has previously been demonstrated to be effective in modulating motor cortical excitability [8].”
Evidence-based guidelines on the therapeutic use of transcranial direct current stimulation (tDCS). (2017, background): “About 15 years ago, tDCS was re-discovered as a tool to modulate human brain activity and its physiological effects started to be systematically explored (Priori et al., 1998; Nitsche and Paulus, 2000).”
Increasing Human Brain Excitability by Transcranial High-Frequency Random Noise Stimulation (2008, background): “Generally, motor cortex (M1) excitability is enhanced by anodal and decreased by cathodal stimulation (Nitsche and Paulus, 2000).”
Facilitation of Implicit Motor Learning by Weak Transcranial Direct Current Stimulation of the Primary Motor Cortex in the Human (2003, background): “Transcranial direct current stimulation (tDCS) of the motor cortex induces prolonged excitability changes in the human: Anodal stimulation increases and cathodal stimulation decreases cortical excitability (Nitsche & Paulus, 2000, 2001).”