Effects of uniform extracellular DC electric fields on excitability in rat hippocampal slices in vitro

By Marom Bikson, M. Inoue, Hiroki Akiyama, J. Deans, J. Fox, H. Miyakawa, John Gordon Ralph Jefferys. Journal of Physiology, 2004

751 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Cognitive Neuroscience, Electrical and Electronic Engineering

View Paper: https://www.semanticscholar.org/paper/8b40749adc5da0d08cbafef82f8c60d4e293fefc

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Citations in the corpus

Role of Cortical Cell Type and Morphology in Sub- and Suprathreshold Uniform Electric Field Stimulation (2009, methodology): “Coronal slices (300 mm) of primary motor cortex (M1) were prepared from male P21-25 Sprague-Dawley rats on a vibratome (Integraslice 7550 PSDS, Campden Instruments, Lafeyette, Indiana) as previously described.(25,47-49) In brief, rats were anesthetized with intraperitoneal ketamine (7.”
Clinical Research with Transcranial Direct Current Stimulation (tDCS): Challenges and Future Directions (2011, positive): “Animal studies have shown that changes in excitability are reflected in both spontaneous firing rates(31,32); and responsiveness to afferent synaptic inputs.(33,34) It is this primary polarization mechanism that underlies the acute effects of low-intensity DC currents on cortical excitability in hum”
The electric field in the cortex during transcranial current stimulation (2013, background): “The choice of this value is arbitrary since for weak electric fields the change in membrane potential varies linearly with the strength of the applied field (Bikson et al., 2004), and therefore there is no “threshold”belowwhich the electricfield has no effect on theneurons.”
Safety of transcranial Direct Current Stimulation: Evidence Based Update 2016 (2016, background): “tDCS safety with respect to seizure induction is underscored by in vitro DCS studies indicating that the electric field threshold for modulating ongoing epileptiform activity (~1 V/m, consistent with a heightened sensitivity to excitability [124]) is more than an order of magnitude lower than intens”
Partially non‐linear stimulation intensity‐dependent effects of direct current stimulation on motor cortex excitability in humans (2013, background): “Another possible mechanism explaining excitatory after-effects of 2 mA cathodal tDCS could be that DC stimulation induces de- and hyperpolarization via hyperpolarizing the soma and depolarizing dendrites, respectively, with cathodal stimulation (Jefferys, 1981; Ghai et al. 2000; Bikson et al. 2004).”
Physiological and modeling evidence for focal transcranial electrical brain stimulation in humans: A basis for high-definition tDCS (2013, result): “…the well-established sensitivity to electric field of bent and terminating processes (Rattay, 1986) as expected in tortuous cortex, as well as sensitivity of compact neurons (Bikson et al., 2004; Joucla and Yvert, 2009; Rattay, 1986); and a posteriori from correlation with our experimental series.”
A technical guide to tDCS, and related non-invasive brain stimulation tools (2015, background): “The filtering properties of the membrane (Bikson et al., 2004) also make the induced polarization frequency specific, with high frequencies less effective in modulating excitability (Deans et al.”
Optimization of multifocal transcranial current stimulation for weighted cortical pattern targeting from realistic modeling of electric fields (2013, positive): “Optimization problem and algorithms The basic mechanism for neuronal interaction in tCS is presently thought to arise from the coupling of electric fields to populations of elongated neurons such as pyramidal cells (Bikson et al., 2004 and references therein).”
Battery powered thought: Enhancement of attention, learning, and memory in healthy adults using transcranial direct current stimulation (2014, positive): “Animal studies also show that anodal DC stimulation of hippocampal slices at low current levels decreases the threshold for neuronal firing (Bikson et al., 2004). Human studies confirm these results; the administration of drugs that alter neuronal sodium and calcium currentsmodulates the acute effec”
Gyri –precise head model of transcranial DC stimulation: Improved spatial focality using a ring electrode versus conventional rectangular pad (2009, positive): “’’ The consideration of the EF (as opposed to the classical activating function) may be appropriate if: (1) tDCS-induced EFs are uniform at the scale of a neuron and (2) neuronal modulation may be directly correlated with uniform EF magnitude.(17,26,37-41) Our EF magnitude modulation maps do not con”
Endogenous Electric Fields May Guide Neocortical Network Activity (2010, positive): “More recent work on the role of weaker EFs in the mammalian brain mostly focused on rodent hippocampus (Bikson et al., 2004; Deans et al., 2007; Dudek et al., 1986; Fujisawa et al., 2004; Ghai et al., 2000; Grenier et al., 2003; Radman et al., 2007; Snow and Dudek, 1984; Vigmond et al., 1997) that…”
Evidence-based guidelines on the therapeutic use of transcranial direct current stimulation (tDCS). (2017, background): “The local cellular influence of DC fields into the brain is complex, depending on the distance and orientation of the axonal or somatodendritic axis with respect to the electric field (Purpura and McMurtry, 1965; Gluckman et al., 1996; Bikson et al., 2004).”
Targeting neural oscillations with transcranial alternating current stimulation (2021, background): “The effect of electrical stimulation on neurons is presumed to arise from depolarization of the somatic compartment of neurons with somato-dendritic axis that is oriented in parallel to the vectors of stimulation current (Bikson, 2004; Radman, 2007).”