The future challenges facing the development of new antimicrobial drugs

By A. Coates, Yanmin Hu, R. Bax, C. Page. Nature reviews. Drug discovery, 2002

718 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Microbial drug discovery: 80 years of progress (2009, background): “24 One additional reason for developing new antibiotics is related to their own toxicity.”
Evolution of the serine β-lactamases: past, present and future (2004, background): “In 2002, the global market for antibiotics was estimated at US$ 25 billion (Coates et al., 2002), of which about 50% was -lactam antibiotics.”
Targeting bacterial membrane function: an underexploited mechanism for treating persistent infections (2010, background): “Consequently, unconventional antimicrobial strategies will be needed to cure infections that contain quiescent bacteria ( Box 2 ), as previously describe”
Isolation and Identification of Bacillus Species From Soil and Evaluation of Their Antibacterial Properties (2015, background): “Screening for new antibiotics from natural sources is becoming increasingly important for the pharmaceutical industry (18), as pathogenic bacteria are significantly becoming resistant to generally used curative agents (19).”
Opinion — anti-infectives: Where will new antibiotics come from? (2003, background): “Current molecules In 2002, the global antibiotic market was estimated at US d25 billio”
Development of nanoparticles for antimicrobial drug delivery. (2010, background): “Since the discovery of antimicrobial drugs in the 1960s [2], many infectious diseases have been overcome.”