Targeting bacterial membrane function: an underexploited mechanism for treating persistent infections

By J. Hurdle, A. O’Neill, I. Chopra, Richard E. Lee. Nature Reviews Microbiology, 2010

818 citations recorded by the source corpus.

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A Deep Learning Approach to Antibiotic Discovery. (2020, neutral): “Moreover, given that cells must maintain an electrochemical transmembrane gradient for viability (Hurdle et al., 2011; Coates and Hu, 2008), dissipation of the proton motive force would result in the death of tolerant cells.”
Discovery of a structural class of antibiotics with explainable deep learning (2023, background): “…mechanism of action 1 and bacterial membrane-sensitive mechanisms of action have often been de-prioritized in antibiotic drug discovery owing in part to potential lack of selectivity 41 , compounds 1 and 2 selectively target Gram-positive bacteria over Gram-negative bacteria and human cells.”
A deep learning approach to antibiotic discovery (2020, background): “Moreover, given that cells must maintain an electrochemical transmembrane gradient for viability (Hurdle et al., 2011; Coates and Hu, 2008), dissipation of the proton motive force would result in the death of tolerant cells.”
Global landscape of cell envelope protein complexes in Escherichia coli (2017, background): “Co-localized to the same compartment 881 (3,351) Bait-prey (or prey–prey) associations with CEPs”