Evolution of the serine β-lactamases: past, present and future

By Barry G. Hall, Miriam Barlow. 2004

296 citations recorded by the source corpus.

Subfields: Endocrinology, Epidemiology, Molecular Medicine

View Paper: https://www.semanticscholar.org/paper/22209c62fdd0aa4faba4a45aeb21a9cc7d1836ae

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In Endocrinology

In Epidemiology

In Molecular Medicine

Citations in the corpus

The epidemic of antibiotic-resistant infections: a call to action for the medical community from the Infectious Diseases Society of America. (2008, unknown): “Genetic analysis of microbial metabolic pathways indicates that microbes invented both b-lactam antibiotics and b-lactamase enzymes to resist those antibiotics 12 billion years ago [60, 61 ].”
Structure-Based Phylogeny of the Metallo-β-Lactamases (2005, methodology): “Most published studies (4, 5, 16 , 26) that include structure-based phylogenies simply assert that normalized RMS distances can be used for phylogenetic reconstruction without presenting a basis for that assertion.”
A Comprehensive, High-Resolution Map of a Gene’s Fitness Landscape (2014, background): “An alternative explanation is that TEM-1, as a product of millions of years of evolution under the standard genetic code (Hall and Barlow 2004), Number of alleles 200 600 400 100 500 300 700 0 0 -1 -2 -3 0 -1 -2 -3 Number of alleles synonymous missense nonsense A B Fitness effect (log 10 w) Fitness…”
The antibiotic resistome: the nexus of chemical and genetic diversity (2007, background): “Even the relatively new antibiotic daptomycin is predicted to be at least 30 million years old! Furthermore, using a structure-based phylogeny, Hall and Barlow estimated that β-lactamases arose over 2 billion years ago, predating the divergence of Gram-positive and Gram-negative bacteri”
A Brief History of the Antibiotic Era: Lessons Learned and Challenges for the Future (2010, background): “Structure-based phylogeny of serine and metallo-β-lactamases, for example, established that these ancient enzymes originated more than two billion years ago, with some serine β-lactamases being present on plasmids for millions of years (Hall and Barlow, 2004; Garau et al., 2005).”
Dissemination of Antimicrobial Resistance in Microbial Ecosystems through Horizontal Gene Transfer (2016, background): “Natural antibiotics have existed for billions of years (Barlow and Hall, 2002; Hall and Barlow, 2004; Bhullar et al., 2012; Wright and Poinar, 2012), providing a selective benefit for the producing strains by inhibiting or eliminating other bacteria competing for resources (Martinez, 2008; Aminov,…”
Antibiotic Resistance Is Prevalent in an Isolated Cave Microbiome (2012, background): “On the other hand, antibiotics and antibiotic biosynthetic pathways are believed to have evolved over millions of years suggesting that antibiotic resistance is an equally ancient phenomenon [5,6,7].”
Antibiotic resistance plasmids in wastewater treatment plants and their possible dissemination into the environment (2010, background): “It is well established that ARB and ARGs existed prior to widespread antibiotic use (Hall and Barlow, 2004; Martinez, 2009a,b; Allen et al., 2010), however, the importance of the non-clinical environment in the increase of antibiotic resistance to clinical pathogens remains unclear (Martinez, 2009a;”